Efficacy and cost-effectiveness analysis of 10-day versus 14-day eradication of Helicobacter pylori infection with vonoprazan amoxicillin: a prospective, multicenter, randomized controlled trial

Efficacy and cost-effectiveness analysis of 10-day versus 14-day eradication of Helicobacter pylori infection with vonoprazan amoxicillin: a prospective, multicenter, randomized controlled trial

ObjectivesTo evaluate the efficacy and cost-effectiveness of 10-day vonoprazan-amoxicillin (VA) dual therapy compared to 14-day VA therapy.MethodsA non-inferiority trial was carried out at 10 clinical centers to recruit patients with H. pylori infection. Subjects were assigned at random to either th...

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Main Authors: Yunfan Dong, Zhaotao Duan, Min Liu, Yanbing Ding, Guangxia Chen, Ruifang Wang, Xiaodan Xu, Lixia Ding, Qiang Zhan, Chengyu Pan, Hui Li, Faming Yang, Xiaorong Dai, Xiangsu Li, Xudong Wu, Peng Peng, Jianrong Wang, Kewei Hu, Duanmin Hu, Qiong Jie, Zhenyu Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Pharmacology
Subjects:
Helicobacter pylori
vonoprazan
amoxicillin
dual therapy
eradication
cost-effectiveness
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1543352/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1543352/full

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