Loss of the TGFβ-activating integrin αvβ8 on dendritic cells protects mice from chronic intestinal parasitic infection via control of type 2 immunity.

Loss of the TGFβ-activating integrin αvβ8 on dendritic cells protects mice from chronic intestinal parasitic infection via control of type 2 immunity.

Chronic intestinal parasite infection is a major global health problem, but mechanisms that promote chronicity are poorly understood. Here we describe a novel cellular and molecular pathway involved in the development of chronic intestinal parasite infection. We show that, early during development o...

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Bibliographic Details
Main Authors: John J Worthington, Joanna E Klementowicz, Sayema Rahman, Beata I Czajkowska, Catherine Smedley, Herman Waldmann, Tim Sparwasser, Richard K Grencis, Mark A Travis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1003675
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https://doi.org/10.1371/journal.ppat.1003675

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