Isosteviol Sodium Promotes Neurological Function Recovery in a Model of Spinal Cord Injury in Rats
ABSTRACT Background Traumatic spinal cord injury (SCI) is an incurable condition that is the largest cause of disability. In previous studies, Isosteviol sodium (STVNa) has been shown to protect rats against acute focal cerebral ischemia; however, the effects of STVNa on SCI recovery in rats remain...
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Wiley
2025-01-01
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| Series: | Immunity, Inflammation and Disease |
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| Online Access: | https://doi.org/10.1002/iid3.70110 |
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| author | Tongxia Zhang Tao Zhang Han Yu Lingyi Chi |
| author_facet | Tongxia Zhang Tao Zhang Han Yu Lingyi Chi |
| author_sort | Tongxia Zhang |
| collection | DOAJ |
| description | ABSTRACT Background Traumatic spinal cord injury (SCI) is an incurable condition that is the largest cause of disability. In previous studies, Isosteviol sodium (STVNa) has been shown to protect rats against acute focal cerebral ischemia; however, the effects of STVNa on SCI recovery in rats remain unknown. Methods STVNa was given intraperitoneally after SCI to see if it had any neuroprotective benefits. On Days 7, 14, 21, and 28 post‐SCI, functional recovery was measured using the Basso, Beattie, and Bresnahan (BBB) scoring system along with the oblique plate test. Following these evaluations, spinal cord tissues were harvested for analysis. All behavioral testing occurred between 8 a.m. and 3 p.m. Results We found that STVNa improved spinal cord functional recovery in rats, as evidenced by enhanced BBB locomotor rating scale, angle of inclination, decreased cavity of spinal cord damage, and neuron death in vivo. In addition, STVNa reduced inflammation in rats following SCI, as demonstrated by a reduction in proinflammatory cytokines such as tumor necrosis factor (TNF)‐α, interleukin (IL)‐6, and interleukin (IL)‐1β. STVNa also reduced oxidative damage in SCI rats by lowering ROS while raising SOD levels. Conclusion These findings suggest that STVNa protects SCI rats through a variety of pathways. STVNa, in particular, may benefit the recovery of SCI by reducing oxidative stress and inflammation, leading to enhanced locomotor activity in rats with SCI. |
| format | Article |
| id | doaj-art-8967f5c22daa4074b63bfff27af360aa |
| institution | Kabale University |
| issn | 2050-4527 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Immunity, Inflammation and Disease |
| spelling | doaj-art-8967f5c22daa4074b63bfff27af360aa2025-02-06T07:50:38ZengWileyImmunity, Inflammation and Disease2050-45272025-01-01131n/an/a10.1002/iid3.70110Isosteviol Sodium Promotes Neurological Function Recovery in a Model of Spinal Cord Injury in RatsTongxia Zhang0Tao Zhang1Han Yu2Lingyi Chi3Research Institute of Neuromuscular and Neurodegenerative Diseases and Department of Neurology Qilu Hospital of Shandong University Jinan Shandong People's Republic of ChinaShandong Qidu Pharmaceutical Co. Ltd. and Shandong Provincial Key Laboratory of Neuroprotective Drugs Zibo Shandong People's Republic of ChinaSchool of Basic Medical Sciences Cheeloo College of Medicine Shandong University Jinan Shandong People's Republic of ChinaSchool of Basic Medical Sciences Cheeloo College of Medicine Shandong University Jinan Shandong People's Republic of ChinaABSTRACT Background Traumatic spinal cord injury (SCI) is an incurable condition that is the largest cause of disability. In previous studies, Isosteviol sodium (STVNa) has been shown to protect rats against acute focal cerebral ischemia; however, the effects of STVNa on SCI recovery in rats remain unknown. Methods STVNa was given intraperitoneally after SCI to see if it had any neuroprotective benefits. On Days 7, 14, 21, and 28 post‐SCI, functional recovery was measured using the Basso, Beattie, and Bresnahan (BBB) scoring system along with the oblique plate test. Following these evaluations, spinal cord tissues were harvested for analysis. All behavioral testing occurred between 8 a.m. and 3 p.m. Results We found that STVNa improved spinal cord functional recovery in rats, as evidenced by enhanced BBB locomotor rating scale, angle of inclination, decreased cavity of spinal cord damage, and neuron death in vivo. In addition, STVNa reduced inflammation in rats following SCI, as demonstrated by a reduction in proinflammatory cytokines such as tumor necrosis factor (TNF)‐α, interleukin (IL)‐6, and interleukin (IL)‐1β. STVNa also reduced oxidative damage in SCI rats by lowering ROS while raising SOD levels. Conclusion These findings suggest that STVNa protects SCI rats through a variety of pathways. STVNa, in particular, may benefit the recovery of SCI by reducing oxidative stress and inflammation, leading to enhanced locomotor activity in rats with SCI.https://doi.org/10.1002/iid3.70110apoptosisinflammationisosteviol sodiumoxidative stressspinal cord injury |
| spellingShingle | Tongxia Zhang Tao Zhang Han Yu Lingyi Chi Isosteviol Sodium Promotes Neurological Function Recovery in a Model of Spinal Cord Injury in Rats Immunity, Inflammation and Disease apoptosis inflammation isosteviol sodium oxidative stress spinal cord injury |
| title | Isosteviol Sodium Promotes Neurological Function Recovery in a Model of Spinal Cord Injury in Rats |
| title_full | Isosteviol Sodium Promotes Neurological Function Recovery in a Model of Spinal Cord Injury in Rats |
| title_fullStr | Isosteviol Sodium Promotes Neurological Function Recovery in a Model of Spinal Cord Injury in Rats |
| title_full_unstemmed | Isosteviol Sodium Promotes Neurological Function Recovery in a Model of Spinal Cord Injury in Rats |
| title_short | Isosteviol Sodium Promotes Neurological Function Recovery in a Model of Spinal Cord Injury in Rats |
| title_sort | isosteviol sodium promotes neurological function recovery in a model of spinal cord injury in rats |
| topic | apoptosis inflammation isosteviol sodium oxidative stress spinal cord injury |
| url | https://doi.org/10.1002/iid3.70110 |
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