Massive Uterine Leiomyoma in a Patient with Friedreich's Ataxia: Is There a Possible Association?
A possible association between Friedreich's ataxia (FA) and neoplastic development has been recognized. FA patients have low frataxin levels and insufficient response to oxidative stress. In these patients fibroblasts are characterized by a high rate of mutations. Herein, a case of a 39-year-ol...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2011/648217 |
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| author | Evangelos P. Misiakos Elli Siama Dimitrios Schizas Constantinos Petropoulos Nikos Zavras Nikos Economopoulos Alexandros Charalabopoulos Anastasios Macheras |
| author_facet | Evangelos P. Misiakos Elli Siama Dimitrios Schizas Constantinos Petropoulos Nikos Zavras Nikos Economopoulos Alexandros Charalabopoulos Anastasios Macheras |
| author_sort | Evangelos P. Misiakos |
| collection | DOAJ |
| description | A possible association between Friedreich's ataxia (FA) and neoplastic development has been recognized. FA patients have low frataxin levels and insufficient response to oxidative stress. In these patients fibroblasts are characterized by a high rate of mutations. Herein, a case of a 39-year-old woman with FA tetraplegia, who was admitted in our department with intestinal obstruction due to a huge uterine tumor, is described. An abdominal CT revealed a huge intra-abdominal mass originating from the right cornu of the uterus. Tumor excision and adhesionlysis were performed. The histological examination of the tumor revealed a leiomyoma. FA patients seem to present with a variety of neoplasms uncommon for their young age. This is the first report of a leiomyoma originating from the genital system in a female patient with FA tetraplegia. Therefore it is important to identify neoplasms at an early stage in patients with FA and start immediate therapy. |
| format | Article |
| id | doaj-art-8965e93adffa4c11a90cc4301e3c0efe |
| institution | Kabale University |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-8965e93adffa4c11a90cc4301e3c0efe2025-02-03T01:02:19ZengWileyCase Reports in Medicine1687-96271687-96352011-01-01201110.1155/2011/648217648217Massive Uterine Leiomyoma in a Patient with Friedreich's Ataxia: Is There a Possible Association?Evangelos P. Misiakos0Elli Siama1Dimitrios Schizas2Constantinos Petropoulos3Nikos Zavras4Nikos Economopoulos5Alexandros Charalabopoulos6Anastasios Macheras73rd Department of Surgery, University of Athens School of Medicine, Attikon University Hospital, Haidari, Athens 12462, Greece3rd Department of Surgery, University of Athens School of Medicine, Attikon University Hospital, Haidari, Athens 12462, GreeceUniversity of Athens School of Medicine, Attikon University Hospital, Haidari, Athens 12462, GreeceUniversity of Athens School of Medicine, Attikon University Hospital, Haidari, Athens 12462, Greece2nd Department of Radiology, University of Athens School of Medicine, Attikon University Hospital, Haidari, Athens 12462, Greece2nd Department of Radiology, University of Athens School of Medicine, Attikon University Hospital, Haidari, Athens 12462, Greece3rd Department of Surgery, University of Athens School of Medicine, Attikon University Hospital, Haidari, Athens 12462, Greece3rd Department of Surgery, University of Athens School of Medicine, Attikon University Hospital, Haidari, Athens 12462, GreeceA possible association between Friedreich's ataxia (FA) and neoplastic development has been recognized. FA patients have low frataxin levels and insufficient response to oxidative stress. In these patients fibroblasts are characterized by a high rate of mutations. Herein, a case of a 39-year-old woman with FA tetraplegia, who was admitted in our department with intestinal obstruction due to a huge uterine tumor, is described. An abdominal CT revealed a huge intra-abdominal mass originating from the right cornu of the uterus. Tumor excision and adhesionlysis were performed. The histological examination of the tumor revealed a leiomyoma. FA patients seem to present with a variety of neoplasms uncommon for their young age. This is the first report of a leiomyoma originating from the genital system in a female patient with FA tetraplegia. Therefore it is important to identify neoplasms at an early stage in patients with FA and start immediate therapy.http://dx.doi.org/10.1155/2011/648217 |
| spellingShingle | Evangelos P. Misiakos Elli Siama Dimitrios Schizas Constantinos Petropoulos Nikos Zavras Nikos Economopoulos Alexandros Charalabopoulos Anastasios Macheras Massive Uterine Leiomyoma in a Patient with Friedreich's Ataxia: Is There a Possible Association? Case Reports in Medicine |
| title | Massive Uterine Leiomyoma in a Patient with Friedreich's Ataxia: Is There a Possible Association? |
| title_full | Massive Uterine Leiomyoma in a Patient with Friedreich's Ataxia: Is There a Possible Association? |
| title_fullStr | Massive Uterine Leiomyoma in a Patient with Friedreich's Ataxia: Is There a Possible Association? |
| title_full_unstemmed | Massive Uterine Leiomyoma in a Patient with Friedreich's Ataxia: Is There a Possible Association? |
| title_short | Massive Uterine Leiomyoma in a Patient with Friedreich's Ataxia: Is There a Possible Association? |
| title_sort | massive uterine leiomyoma in a patient with friedreich s ataxia is there a possible association |
| url | http://dx.doi.org/10.1155/2011/648217 |
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