Changes in Ocular Surface Characteristics after Switching from Benzalkonium Chloride-Preserved Latanoprost to Preservative-Free Tafluprost or Benzalkonium Chloride-Preserved Tafluprost
Purpose. The aim of the present study was to examine the effects of switching from Latanoprost ophthalmic solution containing a preservative to preservative-free Tafluprost ophthalmic solution or Tafluprost containing a preservative on ocular surfaces. Materials and Methods. Forty patients (40 eyes)...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2017/3540749 |
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| author | Naoto Tokuda Yasushi Kitaoka Akiko Matsuzawa Ayaka Tsukamoto Kana Sase Shinsuke Sakae Hitoshi Takagi |
| author_facet | Naoto Tokuda Yasushi Kitaoka Akiko Matsuzawa Ayaka Tsukamoto Kana Sase Shinsuke Sakae Hitoshi Takagi |
| author_sort | Naoto Tokuda |
| collection | DOAJ |
| description | Purpose. The aim of the present study was to examine the effects of switching from Latanoprost ophthalmic solution containing a preservative to preservative-free Tafluprost ophthalmic solution or Tafluprost containing a preservative on ocular surfaces. Materials and Methods. Forty patients (40 eyes) with glaucoma (mean age: 62.0 ± 10.9 years) using Latanoprost with preservative for six months or longer were assigned either to a Tafluprost-containing-preservative group (20 eyes) or preservative-free-Tafluprost group (20 eyes). The intraocular pressure, corneal epithelial barrier function (fluorescein uptake concentration with fluorophotometer FL-500), superficial punctate keratopathy (AD classification), and tear film breakup time (TBUT) were assessed before switching and at 12 weeks after switching. Results. No significant differences in intraocular pressure were noted after switching in either group. Corneal epithelial barrier function was improved significantly after switching in both the Tafluprost-containing-preservative and the preservative-free-Tafluprost groups. There were no significant differences in AD scores after switching in the Tafluprost-containing-preservative group, but significant improvements were noted in the preservative-free-Tafluprost group. No significant differences in TBUT were noted in the Tafluprost-containing-preservative or preservative-free-Tafluprost groups after switching. Conclusion. After switching from preservative Latanoprost to Tafluprost containing-preservative or preservative-free Tafluprost, corneal epithelial barrier function was improved while the intraocular pressure reduction was retained. |
| format | Article |
| id | doaj-art-8936ab86a8b0448e9feabfb16c1fcc4c |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-8936ab86a8b0448e9feabfb16c1fcc4c2025-02-03T01:29:13ZengWileyJournal of Ophthalmology2090-004X2090-00582017-01-01201710.1155/2017/35407493540749Changes in Ocular Surface Characteristics after Switching from Benzalkonium Chloride-Preserved Latanoprost to Preservative-Free Tafluprost or Benzalkonium Chloride-Preserved TafluprostNaoto Tokuda0Yasushi Kitaoka1Akiko Matsuzawa2Ayaka Tsukamoto3Kana Sase4Shinsuke Sakae5Hitoshi Takagi6Department of Ophthalmology, St Marianna University School of Medicine, Kanagawa, JapanDepartment of Ophthalmology, St Marianna University School of Medicine, Kanagawa, JapanDepartment of Ophthalmology, St Marianna University School of Medicine, Kanagawa, JapanDepartment of Ophthalmology, St Marianna University School of Medicine, Kanagawa, JapanDepartment of Ophthalmology, St Marianna University School of Medicine, Kanagawa, JapanDepartment of Ophthalmology, St Marianna University School of Medicine, Kanagawa, JapanDepartment of Ophthalmology, St Marianna University School of Medicine, Kanagawa, JapanPurpose. The aim of the present study was to examine the effects of switching from Latanoprost ophthalmic solution containing a preservative to preservative-free Tafluprost ophthalmic solution or Tafluprost containing a preservative on ocular surfaces. Materials and Methods. Forty patients (40 eyes) with glaucoma (mean age: 62.0 ± 10.9 years) using Latanoprost with preservative for six months or longer were assigned either to a Tafluprost-containing-preservative group (20 eyes) or preservative-free-Tafluprost group (20 eyes). The intraocular pressure, corneal epithelial barrier function (fluorescein uptake concentration with fluorophotometer FL-500), superficial punctate keratopathy (AD classification), and tear film breakup time (TBUT) were assessed before switching and at 12 weeks after switching. Results. No significant differences in intraocular pressure were noted after switching in either group. Corneal epithelial barrier function was improved significantly after switching in both the Tafluprost-containing-preservative and the preservative-free-Tafluprost groups. There were no significant differences in AD scores after switching in the Tafluprost-containing-preservative group, but significant improvements were noted in the preservative-free-Tafluprost group. No significant differences in TBUT were noted in the Tafluprost-containing-preservative or preservative-free-Tafluprost groups after switching. Conclusion. After switching from preservative Latanoprost to Tafluprost containing-preservative or preservative-free Tafluprost, corneal epithelial barrier function was improved while the intraocular pressure reduction was retained.http://dx.doi.org/10.1155/2017/3540749 |
| spellingShingle | Naoto Tokuda Yasushi Kitaoka Akiko Matsuzawa Ayaka Tsukamoto Kana Sase Shinsuke Sakae Hitoshi Takagi Changes in Ocular Surface Characteristics after Switching from Benzalkonium Chloride-Preserved Latanoprost to Preservative-Free Tafluprost or Benzalkonium Chloride-Preserved Tafluprost Journal of Ophthalmology |
| title | Changes in Ocular Surface Characteristics after Switching from Benzalkonium Chloride-Preserved Latanoprost to Preservative-Free Tafluprost or Benzalkonium Chloride-Preserved Tafluprost |
| title_full | Changes in Ocular Surface Characteristics after Switching from Benzalkonium Chloride-Preserved Latanoprost to Preservative-Free Tafluprost or Benzalkonium Chloride-Preserved Tafluprost |
| title_fullStr | Changes in Ocular Surface Characteristics after Switching from Benzalkonium Chloride-Preserved Latanoprost to Preservative-Free Tafluprost or Benzalkonium Chloride-Preserved Tafluprost |
| title_full_unstemmed | Changes in Ocular Surface Characteristics after Switching from Benzalkonium Chloride-Preserved Latanoprost to Preservative-Free Tafluprost or Benzalkonium Chloride-Preserved Tafluprost |
| title_short | Changes in Ocular Surface Characteristics after Switching from Benzalkonium Chloride-Preserved Latanoprost to Preservative-Free Tafluprost or Benzalkonium Chloride-Preserved Tafluprost |
| title_sort | changes in ocular surface characteristics after switching from benzalkonium chloride preserved latanoprost to preservative free tafluprost or benzalkonium chloride preserved tafluprost |
| url | http://dx.doi.org/10.1155/2017/3540749 |
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