Biomechanics in the onset and severity of spondyloarthritis: a force to be reckoned with
Increasing evidence suggests that there is a pivotal role for physical force (mechanotransduction) in the initiation and/or the perpetuation of spondyloarthritis; the review contained herein examines that evidence. Furthermore, we know that damage and inflammation can limit spinal mobility, but is t...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2023-11-01
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| Series: | RMD Open |
| Online Access: | https://rmdopen.bmj.com/content/9/4/e003372.full |
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| author | Mark Hwang Priyanka Iyer Lauren Ridley Michael M Weisman |
| author_facet | Mark Hwang Priyanka Iyer Lauren Ridley Michael M Weisman |
| author_sort | Mark Hwang |
| collection | DOAJ |
| description | Increasing evidence suggests that there is a pivotal role for physical force (mechanotransduction) in the initiation and/or the perpetuation of spondyloarthritis; the review contained herein examines that evidence. Furthermore, we know that damage and inflammation can limit spinal mobility, but is there a cycle created by altered spinal mobility leading to additional damage and inflammation?Over the past several years, mechanotransduction, the mechanism by which mechanical perturbation influences gene expression and cellular behaviour, has recently gained popularity because of emerging data from both animal models and human studies of the pathogenesis of ankylosing spondylitis (AS). In this review, we provide evidence towards an appreciation of the unsolved paradigm of how biomechanical forces may play a role in the initiation and propagation of AS. |
| format | Article |
| id | doaj-art-891d2f0c7c754a3882b1b8d1d8ab1fba |
| institution | Kabale University |
| issn | 2056-5933 |
| language | English |
| publishDate | 2023-11-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | RMD Open |
| spelling | doaj-art-891d2f0c7c754a3882b1b8d1d8ab1fba2025-02-03T09:15:14ZengBMJ Publishing GroupRMD Open2056-59332023-11-019410.1136/rmdopen-2023-003372Biomechanics in the onset and severity of spondyloarthritis: a force to be reckoned withMark Hwang0Priyanka Iyer1Lauren Ridley2Michael M Weisman3Rheumatology, The University of Texas Health Science Center at Houston John P and Katherine G McGovern Medical School, Houston, Texas, USAUniversity of Iowa Hospitals and Clinics, Rheumatology, Iowa City, United States of AmericaRheumatology, The University of Texas Health Science Center at Houston John P and Katherine G McGovern Medical School, Houston, Texas, USARheumatology, Stanford University, Stanford, California, USAIncreasing evidence suggests that there is a pivotal role for physical force (mechanotransduction) in the initiation and/or the perpetuation of spondyloarthritis; the review contained herein examines that evidence. Furthermore, we know that damage and inflammation can limit spinal mobility, but is there a cycle created by altered spinal mobility leading to additional damage and inflammation?Over the past several years, mechanotransduction, the mechanism by which mechanical perturbation influences gene expression and cellular behaviour, has recently gained popularity because of emerging data from both animal models and human studies of the pathogenesis of ankylosing spondylitis (AS). In this review, we provide evidence towards an appreciation of the unsolved paradigm of how biomechanical forces may play a role in the initiation and propagation of AS.https://rmdopen.bmj.com/content/9/4/e003372.full |
| spellingShingle | Mark Hwang Priyanka Iyer Lauren Ridley Michael M Weisman Biomechanics in the onset and severity of spondyloarthritis: a force to be reckoned with RMD Open |
| title | Biomechanics in the onset and severity of spondyloarthritis: a force to be reckoned with |
| title_full | Biomechanics in the onset and severity of spondyloarthritis: a force to be reckoned with |
| title_fullStr | Biomechanics in the onset and severity of spondyloarthritis: a force to be reckoned with |
| title_full_unstemmed | Biomechanics in the onset and severity of spondyloarthritis: a force to be reckoned with |
| title_short | Biomechanics in the onset and severity of spondyloarthritis: a force to be reckoned with |
| title_sort | biomechanics in the onset and severity of spondyloarthritis a force to be reckoned with |
| url | https://rmdopen.bmj.com/content/9/4/e003372.full |
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