Phytochemical profiling and in silico evaluation of Artemisia absinthium compounds targeting Leishmania N-myristoyltransferase: molecular docking, drug-likeness, and toxicity analyses

Phytochemical profiling and in silico evaluation of Artemisia absinthium compounds targeting Leishmania N-myristoyltransferase: molecular docking, drug-likeness, and toxicity analyses

BackgroundArtemisia absinthium has long been recognized for its therapeutic properties against various diseases. Among these is leishmaniasis, a parasitic infection that remains a global health challenge. Targeting Leishmania N-myristoyltransferase (NMT), a crucial enzyme for parasite survival, repr...

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Bibliographic Details
Main Authors: Farouk Boudou, Amal Belakredar, Alaeddine Berkane, Ahcen Keziz, Huda Alsaeedi, David Cornu, Mikhael Bechelany, Ahmed Barhoum
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Chemistry
Subjects:
Artemisia absinthium
Leishmania
N-myristoyltransferase
molecular docking
molecular dynamics
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2024.1508603/full
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https://www.frontiersin.org/articles/10.3389/fchem.2024.1508603/full

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