An optimized integrin α6-targeted peptide capable of delivering toxins for melanoma treatment

An optimized integrin α6-targeted peptide capable of delivering toxins for melanoma treatment

Abstract Background Peptide-based therapeutics for melanoma have received increasing attention in medical research. However, the local delivery of such therapeutics poses unique challenges. Cell-penetrating peptides (CPPs) with the ability to selectively enter cancer cells, with sufficient stability...

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Main Authors: Zheng Zhao, Zi-Qian Li, Ying-Bin Huang, Meng-meng Liu, Fei Cao, Guo-Long Bu, Peng-Fei Xu, Qi Fang, Zhu-Long Hu, Di Wu, Guo-Kai Feng, Xue-Kui Liu
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Journal of Translational Medicine
Subjects:
Integrin α6
4S5NG CPP
Pyroptosis
Antitumor immunity
Melanoma
Online Access:https://doi.org/10.1186/s12967-025-06511-5
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https://doi.org/10.1186/s12967-025-06511-5

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