Detrimental role of IL-33/ST2 pathway sustaining a chronic eosinophil-dependent Th2 inflammatory response, tissue damage and parasite burden during Toxocara canis infection in mice.

Detrimental role of IL-33/ST2 pathway sustaining a chronic eosinophil-dependent Th2 inflammatory response, tissue damage and parasite burden during Toxocara canis infection in mice.

Toxocariasis is a neglected disease that affects people around the world. Humans become infected by accidental ingestion of eggs containing Toxocara canis infective larvae, which upon reaching the intestine, hatch, penetrate the mucosa and migrate to various tissues such as liver, lungs and brain. S...

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Main Authors: Thaís Leal-Silva, Flaviane Vieira-Santos, Fabrício Marcus Silva Oliveira, Luiza de Lima Silva Padrão, Lucas Kraemer, Pablo Hemanoel da Paixão Matias, Camila de Almeida Lopes, Ana Cristina Loiola Ruas, Isabella Carvalho de Azevedo, Denise Silva Nogueira, Milene Alvarenga Rachid, Marcelo Vidigal Caliari, Remo Castro Russo, Ricardo Toshio Fujiwara, Lilian Lacerda Bueno
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-07-01
Series:PLoS Neglected Tropical Diseases
Online Access:https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0009639&type=printable
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