Early Infant Feeding Practices as Possible Risk Factors for Immunoglobulin E-Mediated Food Allergies in Kuwait
Objective. Early feeding and infant exposures have been suggested as potential risk factors for immunoglobulin E- (IgE-) mediated food allergy (FA). We aimed to evaluate the association between IgE-mediated FA in children and early exposures including the child’s nutritional status, breastfeeding an...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | International Journal of Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2018/1701903 |
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| _version_ | 1832564343960502272 |
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| author | Dalal Alkazemi Munirah Albeajan Stan Kubow |
| author_facet | Dalal Alkazemi Munirah Albeajan Stan Kubow |
| author_sort | Dalal Alkazemi |
| collection | DOAJ |
| description | Objective. Early feeding and infant exposures have been suggested as potential risk factors for immunoglobulin E- (IgE-) mediated food allergy (FA). We aimed to evaluate the association between IgE-mediated FA in children and early exposures including the child’s nutritional status, breastfeeding and its duration, the age at which the solid food was first introduced, antibiotic exposure during the first year of life, and the child’s vitamin D status during infancy. Design. A case-control study. Setting and Subjects. Children aged 0–13 years were recruited from pediatric allergy and immunology clinics (PAICs) located at major government hospitals in Kuwait (total FA cases: n=100; boys = 67%), and healthy controls (n=100, boys 55%) were recruited from various vaccination units at primary healthcare centers. Results. Cow’s milk allergy was the most common type of FA. FA status was independently associated with the early exposures of exclusive breastfeeding (aOR = 15.55 (3.26–74.19), p=0.001), vitamin D deficiency or insufficiency during infancy (aOR = 5.42 (1.92–15.30), p=0.001), and antibiotic exposure during the first year of life (aOR = 5.00 (1.58–15.84), p=0.006). Conclusions. FA is highly prevalent among children in Kuwait, and our data indicate that early nutrition-related and antibiotic exposures are associated with FA risk. |
| format | Article |
| id | doaj-art-88d2fce8eb8d4582be4c42aac40cb9d3 |
| institution | Kabale University |
| issn | 1687-9740 1687-9759 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Pediatrics |
| spelling | doaj-art-88d2fce8eb8d4582be4c42aac40cb9d32025-02-03T01:11:14ZengWileyInternational Journal of Pediatrics1687-97401687-97592018-01-01201810.1155/2018/17019031701903Early Infant Feeding Practices as Possible Risk Factors for Immunoglobulin E-Mediated Food Allergies in KuwaitDalal Alkazemi0Munirah Albeajan1Stan Kubow2Department of Food Science and Nutrition, College of Life Sciences, Kuwait University, KuwaitDepartment of Food Science and Nutrition, College of Life Sciences, Kuwait University, KuwaitSchool of Human Nutrition, McGill University, 21,111 Lakeshore, Ste-Anne-de-Bellevue, QC H9X3V9, CanadaObjective. Early feeding and infant exposures have been suggested as potential risk factors for immunoglobulin E- (IgE-) mediated food allergy (FA). We aimed to evaluate the association between IgE-mediated FA in children and early exposures including the child’s nutritional status, breastfeeding and its duration, the age at which the solid food was first introduced, antibiotic exposure during the first year of life, and the child’s vitamin D status during infancy. Design. A case-control study. Setting and Subjects. Children aged 0–13 years were recruited from pediatric allergy and immunology clinics (PAICs) located at major government hospitals in Kuwait (total FA cases: n=100; boys = 67%), and healthy controls (n=100, boys 55%) were recruited from various vaccination units at primary healthcare centers. Results. Cow’s milk allergy was the most common type of FA. FA status was independently associated with the early exposures of exclusive breastfeeding (aOR = 15.55 (3.26–74.19), p=0.001), vitamin D deficiency or insufficiency during infancy (aOR = 5.42 (1.92–15.30), p=0.001), and antibiotic exposure during the first year of life (aOR = 5.00 (1.58–15.84), p=0.006). Conclusions. FA is highly prevalent among children in Kuwait, and our data indicate that early nutrition-related and antibiotic exposures are associated with FA risk.http://dx.doi.org/10.1155/2018/1701903 |
| spellingShingle | Dalal Alkazemi Munirah Albeajan Stan Kubow Early Infant Feeding Practices as Possible Risk Factors for Immunoglobulin E-Mediated Food Allergies in Kuwait International Journal of Pediatrics |
| title | Early Infant Feeding Practices as Possible Risk Factors for Immunoglobulin E-Mediated Food Allergies in Kuwait |
| title_full | Early Infant Feeding Practices as Possible Risk Factors for Immunoglobulin E-Mediated Food Allergies in Kuwait |
| title_fullStr | Early Infant Feeding Practices as Possible Risk Factors for Immunoglobulin E-Mediated Food Allergies in Kuwait |
| title_full_unstemmed | Early Infant Feeding Practices as Possible Risk Factors for Immunoglobulin E-Mediated Food Allergies in Kuwait |
| title_short | Early Infant Feeding Practices as Possible Risk Factors for Immunoglobulin E-Mediated Food Allergies in Kuwait |
| title_sort | early infant feeding practices as possible risk factors for immunoglobulin e mediated food allergies in kuwait |
| url | http://dx.doi.org/10.1155/2018/1701903 |
| work_keys_str_mv | AT dalalalkazemi earlyinfantfeedingpracticesaspossibleriskfactorsforimmunoglobulinemediatedfoodallergiesinkuwait AT munirahalbeajan earlyinfantfeedingpracticesaspossibleriskfactorsforimmunoglobulinemediatedfoodallergiesinkuwait AT stankubow earlyinfantfeedingpracticesaspossibleriskfactorsforimmunoglobulinemediatedfoodallergiesinkuwait |