Molecular Alterations of PI3K/Akt/mTOR Pathway: A Therapeutic Target in Endometrial Cancer
It is well established that the PI3K/Akt/mTOR pathway plays a central role in cell growth and proliferation. It has also been suggested that its deregulation is associated with cancer. Genetic alterations, involving components of this pathway, are often encountered in endometrial cancers. Understand...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/709736 |
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| _version_ | 1832552577710948352 |
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| author | Athanasia Pavlidou Nikos F. Vlahos |
| author_facet | Athanasia Pavlidou Nikos F. Vlahos |
| author_sort | Athanasia Pavlidou |
| collection | DOAJ |
| description | It is well established that the PI3K/Akt/mTOR pathway plays a central role in cell growth and proliferation. It has also been suggested that its deregulation is associated with cancer. Genetic alterations, involving components of this pathway, are often encountered in endometrial cancers. Understanding and identifying the rate-limiting steps of this pathway would be crucial for the development of novel therapies against endometrial cancer. This paper reviews alterations in the PI3K/Akt pathway, which could possibly contribute to the development of endometrial cancer. In addition, potential therapeutic targets of this pathway with emphasis on the mTOR inhibitors are also presented. |
| format | Article |
| id | doaj-art-88cfef827c6e4bba913b4616a4381879 |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-88cfef827c6e4bba913b4616a43818792025-02-03T05:58:19ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/709736709736Molecular Alterations of PI3K/Akt/mTOR Pathway: A Therapeutic Target in Endometrial CancerAthanasia Pavlidou0Nikos F. Vlahos1Second Department of Obstetrics and Gynecology, University of Athens Medical School, Aretaieion University Hospital, 76 Vas. Sofias Avenue, 11527 Athens, GreeceSecond Department of Obstetrics and Gynecology, University of Athens Medical School, Aretaieion University Hospital, 76 Vas. Sofias Avenue, 11527 Athens, GreeceIt is well established that the PI3K/Akt/mTOR pathway plays a central role in cell growth and proliferation. It has also been suggested that its deregulation is associated with cancer. Genetic alterations, involving components of this pathway, are often encountered in endometrial cancers. Understanding and identifying the rate-limiting steps of this pathway would be crucial for the development of novel therapies against endometrial cancer. This paper reviews alterations in the PI3K/Akt pathway, which could possibly contribute to the development of endometrial cancer. In addition, potential therapeutic targets of this pathway with emphasis on the mTOR inhibitors are also presented.http://dx.doi.org/10.1155/2014/709736 |
| spellingShingle | Athanasia Pavlidou Nikos F. Vlahos Molecular Alterations of PI3K/Akt/mTOR Pathway: A Therapeutic Target in Endometrial Cancer The Scientific World Journal |
| title | Molecular Alterations of PI3K/Akt/mTOR Pathway: A Therapeutic Target in Endometrial Cancer |
| title_full | Molecular Alterations of PI3K/Akt/mTOR Pathway: A Therapeutic Target in Endometrial Cancer |
| title_fullStr | Molecular Alterations of PI3K/Akt/mTOR Pathway: A Therapeutic Target in Endometrial Cancer |
| title_full_unstemmed | Molecular Alterations of PI3K/Akt/mTOR Pathway: A Therapeutic Target in Endometrial Cancer |
| title_short | Molecular Alterations of PI3K/Akt/mTOR Pathway: A Therapeutic Target in Endometrial Cancer |
| title_sort | molecular alterations of pi3k akt mtor pathway a therapeutic target in endometrial cancer |
| url | http://dx.doi.org/10.1155/2014/709736 |
| work_keys_str_mv | AT athanasiapavlidou molecularalterationsofpi3kaktmtorpathwayatherapeutictargetinendometrialcancer AT nikosfvlahos molecularalterationsofpi3kaktmtorpathwayatherapeutictargetinendometrialcancer |