Characterization of a thermostable uricase derived from Thermoactinospora rubra YIM 77501T and its heat-resistant mechanism

Characterization of a thermostable uricase derived from Thermoactinospora rubra YIM 77501T and its heat-resistant mechanism

IntroductionUricases are oxidative enzymes that catalyze the conversion of uric acid to allantoin and hydrogen peroxide, widely utilized in uric acid testing and the treatment of gout, hyperuricemia, and Tumor Lysis Syndrome (TLS). The search for uricases with long-term thermostability has become a...

Full description

Saved in:

Bibliographic Details
Main Authors:	Xin Yan, Lan-Xin Tang, Maite Ortúzar, Li-Quan Yang, Peng Sang, Na-Ying Jin, Lin-Hua Li, Zheng-Feng Yang, Yan-Wen Wang, Wen-Jun Li, Wei Hu, Yi-Rui Yin
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-06-01
Series:	Frontiers in Microbiology
Subjects:	uricase Thermoactinospora rubra YIM 77501T thermostable heat-resistant mechanism degrade uric acid
Online Access:	https://www.frontiersin.org/articles/10.3389/fmicb.2025.1615845/full
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Characterization, thermostable mechanism, and molecular docking of a novel glucose-tolerant β-glucosidase/β-galactosidase from the GH1 family isolated from Rehai hot spring
by: Yu-Ying Huang, et al.
Published: (2025-04-01)

Highly Stable White Light-Emitting Diodes Based on Quantum-Dots Dispersed Into the Backlight Lens for Display Backlight
by: Xin Yang, et al.
Published: (2019-01-01)

Resolving a nearly 95-year-old enigma: Transfer of the little-known Japanese moss Arctoa schistioides to Kiaeria falcata (Rhabdoweisiaceae, Bryophyta)
by: Wen-Zhuan Huang, et al.
Published: (2025-03-01)

Utilization of Cardiac Magnetic Resonance Imaging for Assessing Myocardial Fibrosis in Prognosis Evaluation and Risk Stratification of Patients with Dilated Cardiomyopathy
by: Xin-Yi Feng, et al.
Published: (2025-01-01)

12/15-lipoxygenase mediates disturbed flow-induced endothelial dysfunction and atherosclerosis
by: Jia Wei Chen, et al.
Published: (2025-07-01)

Cloning and eukaryotic expression of a new MSTN gene transcription of Muscovy duck
by: HAO Wen-bo, et al.
Published: (2009-07-01)

Countermovement jump and reactive strength index of artistic gymnasts improve more with cluster-based plyometric training than with traditional methods
by: DeSen Feng, et al.
Published: (2024-10-01)

Severe Acute Pancreatitis Complicated by Multiple Intra-Abdominal Hemorrhages
by: Cong-Yu Wang, et al.
Published: (2025-02-01)

Research and validation of forest carbon sequestration measurement model based on biomass method-A case study of Guizhou Province.
by: Zhang Min, et al.
Published: (2025-01-01)

Multi‐Omics Analysis Reveals Disturbances of Purine Metabolism and Glutamate Metabolism in the Hippocampus of Lipopolysaccharide‐Induced Mouse Model of Depression
by: Wen‐Wen Li, et al.
Published: (2025-05-01)

Mechanistic insights into the Bushen Huatan Huoxue Formula and its components in ameliorating obesity-associated polycystic ovary syndrome
by: Yu-Xin Jin, et al.
Published: (2025-07-01)

Quality identification of Amomi fructus using E-nose, HS-GC-IMS, and intelligent data fusion methods
by: Pan-Pan Zhang, et al.
Published: (2025-02-01)

Lactobacillus brevis YNH inhibits proliferation of HeLa cells and promotes their apoptosis by modulating the PI3K/AKT pathway
by: Liang He, et al.
Published: (2025-03-01)

Effects of β-Cyclodextrin and Sodium Ascorbate on the Chemical Compositions and Sensory Quality of Instant Green Tea Powder during Storage
by: Yan-Hong Zhang, et al.
Published: (2019-01-01)

The association of triglyceride glucose index and postoperative outcome in patients with severe spontaneous intracerebral hemorrhage: a multiple-center cohort study
by: Haishuang Tang, et al.
Published: (2025-05-01)

Effect of naphthalene acetic acid on adventitious root development and associated physiological changes in stem cutting of Hemarthria compressa.
by: Yan-Hong Yan, et al.
Published: (2014-01-01)

Bevacizumab-associated glomerular microangiopathy: a case report and literature review
by: Rui Jiang, et al.
Published: (2025-08-01)

DSF-YOLO for robust multiscale traffic sign detection under adverse weather conditions
by: Jun Li, et al.
Published: (2025-07-01)

Hs-CRP/HDL-C ratio as a predictive inflammatory-lipid marker for sarcopenia: evidence from NHANES 2015–2018
by: Xin-Yan Guo, et al.
Published: (2025-06-01)

Activity Expression and Property Analysis of Codon-Optimized Polyphenol Oxidase from <i>Camellia sinensis</i> in <i>Pichia pastoris</i> KM71
by: Xin Zhang, et al.
Published: (2025-08-01)

Blind audio watermarking mechanism based on variational Bayesian learning
by: Xin TANG, et al.
Published: (2015-01-01)

Effect of Ablation Material and Deuterium-tritium Ice Profile on Cryogenic Target Thermal Fields
by: Li Cui, et al.
Published: (2020-01-01)

Increased tau-induced inflammatory responses are associated with a greater degree of atherosclerosis in progressive supranuclear palsy
by: Yi-Xin He, et al.
Published: (2025-08-01)

Genome-Wide Identification, Characterization, and Expression Analysis of the NAC Transcription Factor Family in Sweet Cherry (<i>Prunus avium</i> L.)
by: Feng An, et al.
Published: (2025-04-01)

Strong Convergence of a Unified General Iteration for k-Strictly Pseudononspreading Mapping in Hilbert Spaces
by: Dao-Jun Wen, et al.
Published: (2014-01-01)

Correlation between the use of dried Toad skin-radix clematidis and the development of intestinal dysbiosis and colorectal cancer
by: Xue-yan Wang, et al.
Published: (2025-06-01)

Maintenance of flower color dimorphism in Ophiorrhiza japonica (Rubiaceae): responses to fluctuating temperatures in a dolomite Karst region
by: Xiao-Yue Wang, et al.
Published: (2024-12-01)

Present situation and risk factors of hemodialysis with central venous catheter in patients with first autogenous arteriovenous fistula
by: LU Wen-wen, et al.
Published: (2018-01-01)

Optimizing Green Spaces Significantly Improves Wind Environment and Accessibility in County Towns
by: Dan-Yin Zhang, et al.
Published: (2025-03-01)

Scleral Buckling with Viscoelastics or Gas Injection for Bulging Retinal Detachments: A Retrospective Cohort Study
by: Quan-Yong Yi, et al.
Published: (2021-01-01)

A central and unified role of corticocortical feedback in parsing visual scenes
by: Ye Xin, et al.
Published: (2025-07-01)

A Design of Security Oriented Mobile Robot Control System
by: YAN Yi-xin, et al.
Published: (2019-10-01)

Study on the influence of the sY1192 gene locus in the AZFb/c region on sperm quality and pregnancy outcome
by: Gang-Xin Chen, et al.
Published: (2025-03-01)

Flavonoid-Rich Extracts from Chuju (<i>Asteraceae Chrysanthemum</i> L.) Alleviate the Disturbance of Glycolipid Metabolism on Type 2 Diabetic Mice via Modulating the Gut Microbiota
by: Yu Yin, et al.
Published: (2025-02-01)

Hope therapy brings hope: an empirical study of a curriculum intervention to enhance school adaptation of Chinese high school freshmen
by: Zuobing Deng, et al.
Published: (2025-04-01)

Research on Influencing Factors of Knowledge Hiding Behavior in Socialized Q&A Communities: Taking Zhihu as an Example
by: Wen-Zhu Li, et al.
Published: (2022-01-01)

FINITE ELEMENT ANALYSIS AND OPTIMUM DESIGN OF THE MAGNETIC TRANSMISSION
by: YIN XinQuan, et al.
Published: (2015-01-01)

Displaced heavy neutral lepton from new Higgs doublet
by: Fa-Xin Yang, et al.
Published: (2025-04-01)

Viral Live‐Attenuated Vaccines (LAVs): Past and Future Directions
by: Yan‐Dong Tang, et al.
Published: (2025-01-01)

Large-Scale Sampling Reveals the Strain-Level Diversity of <i>Burkholderia</i> Symbionts in <i>Riptortus pedestris</i> and <i>R. linearis</i> (Hemiptera: Alydidae)
by: Xin-Rui Hou, et al.
Published: (2024-09-01)