Obesity drives depot-specific vascular remodeling in male white adipose tissue

Obesity drives depot-specific vascular remodeling in male white adipose tissue

Abstract Obesity-driven pathological expansion of white adipose tissue (WAT) is a key driver of endothelial dysfunction. However, early vascular alterations associated with over-nutrition also serve to exacerbate WAT dysfunction. Here, we conduct a single-cell transcriptomic analysis of WAT endothel...

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Main Authors: Sana S. Hasan, David John, Martina Rudnicki, Ibrahim AlZaim, Daniel Eberhard, Iris Moll, Jacqueline Taylor, Christian Klein, Maximilian von Heesen, Lena-Christin Conradi, Ralf H. Adams, Eckhard Lammert, Joanna Kalucka, Christiana Ruhrberg, Stefanie Dimmeler, Andreas Fischer
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60910-2
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https://doi.org/10.1038/s41467-025-60910-2

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