miR-155 Predicts Long-Term Mortality in Critically Ill Patients Younger than 65 Years
Introduction. Alterations in miR-155 serum levels have been described in inflammatory and infectious diseases. Moreover, a role for miR-155 in aging and age-related diseases was recently suggested. We therefore analyzed a potential age-dependent prognostic value of circulating miR-155 as a serum-bas...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2019/6714080 |
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| author | Frank Tacke Martina E. Spehlmann Mihael Vucur Fabian Benz Mark Luedde David Vargas Cardenas Sanchari Roy Sven Loosen Hans-Joerg Hippe Norbert Frey Christian Trautwein Alexander Koch Christoph Roderburg Tom Luedde |
| author_facet | Frank Tacke Martina E. Spehlmann Mihael Vucur Fabian Benz Mark Luedde David Vargas Cardenas Sanchari Roy Sven Loosen Hans-Joerg Hippe Norbert Frey Christian Trautwein Alexander Koch Christoph Roderburg Tom Luedde |
| author_sort | Frank Tacke |
| collection | DOAJ |
| description | Introduction. Alterations in miR-155 serum levels have been described in inflammatory and infectious diseases. Moreover, a role for miR-155 in aging and age-related diseases was recently suggested. We therefore analyzed a potential age-dependent prognostic value of circulating miR-155 as a serum-based marker in critical illness. Methods. Concentrations of circulating miR-155 were determined in 218 critically ill patients and 76 healthy controls. Results. By using qPCR, we demonstrate that miR-155 serum levels are elevated in patients with critical illness when compared to controls. Notably, levels of circulating miR-155 were independent on the severity of disease, the disease etiology, or the presence of sepsis. In the total cohort, miR-155 was not an indicator for patient survival. Intriguingly, when patients were subdivided according to their age upon admission to the ICU into those younger than 65 years, lower levels of miR-155 turned out as a strong marker, indicating patient mortality with a similar accuracy than other markers frequently used to evaluate critically ill patients on a medical ICU. Conclusion. In summary, the data provided within this study suggest an age-specific role of miR-155 as a prognostic biomarker in patients younger than 65 years. Our study is the first to describe an age-dependent miRNA-based prognostic biomarker in human diseases. |
| format | Article |
| id | doaj-art-889fa0170f0e4be398a1ab7cd38e4e30 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-889fa0170f0e4be398a1ab7cd38e4e302025-02-03T01:25:36ZengWileyMediators of Inflammation0962-93511466-18612019-01-01201910.1155/2019/67140806714080miR-155 Predicts Long-Term Mortality in Critically Ill Patients Younger than 65 YearsFrank Tacke0Martina E. Spehlmann1Mihael Vucur2Fabian Benz3Mark Luedde4David Vargas Cardenas5Sanchari Roy6Sven Loosen7Hans-Joerg Hippe8Norbert Frey9Christian Trautwein10Alexander Koch11Christoph Roderburg12Tom Luedde13Department of Medicine III, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, GermanyDepartment of Internal Medicine III, University of Kiel, Schittenhelmstrasse 12, 24105 Kiel, GermanyDepartment of Medicine III, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, GermanyDepartment of Medicine III, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, GermanyDepartment of Internal Medicine III, University of Kiel, Schittenhelmstrasse 12, 24105 Kiel, GermanyDepartment of Medicine III, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, GermanyDepartment of Medicine III, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, GermanyDepartment of Medicine III, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, GermanyDepartment of Internal Medicine III, University of Kiel, Schittenhelmstrasse 12, 24105 Kiel, GermanyDepartment of Internal Medicine III, University of Kiel, Schittenhelmstrasse 12, 24105 Kiel, GermanyDepartment of Medicine III, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, GermanyDepartment of Medicine III, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, GermanyDepartment of Medicine III, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, GermanyDepartment of Medicine III, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, GermanyIntroduction. Alterations in miR-155 serum levels have been described in inflammatory and infectious diseases. Moreover, a role for miR-155 in aging and age-related diseases was recently suggested. We therefore analyzed a potential age-dependent prognostic value of circulating miR-155 as a serum-based marker in critical illness. Methods. Concentrations of circulating miR-155 were determined in 218 critically ill patients and 76 healthy controls. Results. By using qPCR, we demonstrate that miR-155 serum levels are elevated in patients with critical illness when compared to controls. Notably, levels of circulating miR-155 were independent on the severity of disease, the disease etiology, or the presence of sepsis. In the total cohort, miR-155 was not an indicator for patient survival. Intriguingly, when patients were subdivided according to their age upon admission to the ICU into those younger than 65 years, lower levels of miR-155 turned out as a strong marker, indicating patient mortality with a similar accuracy than other markers frequently used to evaluate critically ill patients on a medical ICU. Conclusion. In summary, the data provided within this study suggest an age-specific role of miR-155 as a prognostic biomarker in patients younger than 65 years. Our study is the first to describe an age-dependent miRNA-based prognostic biomarker in human diseases.http://dx.doi.org/10.1155/2019/6714080 |
| spellingShingle | Frank Tacke Martina E. Spehlmann Mihael Vucur Fabian Benz Mark Luedde David Vargas Cardenas Sanchari Roy Sven Loosen Hans-Joerg Hippe Norbert Frey Christian Trautwein Alexander Koch Christoph Roderburg Tom Luedde miR-155 Predicts Long-Term Mortality in Critically Ill Patients Younger than 65 Years Mediators of Inflammation |
| title | miR-155 Predicts Long-Term Mortality in Critically Ill Patients Younger than 65 Years |
| title_full | miR-155 Predicts Long-Term Mortality in Critically Ill Patients Younger than 65 Years |
| title_fullStr | miR-155 Predicts Long-Term Mortality in Critically Ill Patients Younger than 65 Years |
| title_full_unstemmed | miR-155 Predicts Long-Term Mortality in Critically Ill Patients Younger than 65 Years |
| title_short | miR-155 Predicts Long-Term Mortality in Critically Ill Patients Younger than 65 Years |
| title_sort | mir 155 predicts long term mortality in critically ill patients younger than 65 years |
| url | http://dx.doi.org/10.1155/2019/6714080 |
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