Mapping chromatin remodelling in glioblastoma identifies epigenetic regulation of key molecular pathways and novel druggable targets
Abstract Background Glioblastoma is the most common and aggressive malignant brain tumour in the adult population and its prognosis is dismal. The heterogeneous nature of the tumour, to which epigenetic dysregulation significantly contributes, is among the main therapeutic challenges of the disease....
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| Format: | Article |
| Language: | English |
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BMC
2025-02-01
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| Series: | BMC Biology |
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| Online Access: | https://doi.org/10.1186/s12915-025-02127-9 |
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| author | Claire Vinel James Boot Weiwei Jin Nicola Pomella Alexandra Hadaway Charles Mein Nicolae Radu Zabet Silvia Marino |
| author_facet | Claire Vinel James Boot Weiwei Jin Nicola Pomella Alexandra Hadaway Charles Mein Nicolae Radu Zabet Silvia Marino |
| author_sort | Claire Vinel |
| collection | DOAJ |
| description | Abstract Background Glioblastoma is the most common and aggressive malignant brain tumour in the adult population and its prognosis is dismal. The heterogeneous nature of the tumour, to which epigenetic dysregulation significantly contributes, is among the main therapeutic challenges of the disease. Results We have leveraged SYNGN, an experimental pipeline enabling the syngeneic comparison of glioblastoma stem cells and expanded potential stem cell (EPSC)-derived neural stem cells to identify regulatory features driven by chromatin remodelling specifically in glioblastoma stem cells. Conclusions We show epigenetic regulation of the expression of genes and related signalling pathways contributing to glioblastoma development. We also identify novel epigenetically regulated druggable target genes on a patient-specific level, including SMOX and GABBR2. |
| format | Article |
| id | doaj-art-88807a8a8b1e42c398de48d554100b5f |
| institution | Kabale University |
| issn | 1741-7007 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Biology |
| spelling | doaj-art-88807a8a8b1e42c398de48d554100b5f2025-02-09T12:54:21ZengBMCBMC Biology1741-70072025-02-0123112210.1186/s12915-025-02127-9Mapping chromatin remodelling in glioblastoma identifies epigenetic regulation of key molecular pathways and novel druggable targetsClaire Vinel0James Boot1Weiwei Jin2Nicola Pomella3Alexandra Hadaway4Charles Mein5Nicolae Radu Zabet6Silvia Marino7Brain Tumour Research Centre, Faculty of Medicine and Dentistry, Blizard Institute, Queen Mary University LondonBrain Tumour Research Centre, Faculty of Medicine and Dentistry, Blizard Institute, Queen Mary University LondonBrain Tumour Research Centre, Faculty of Medicine and Dentistry, Blizard Institute, Queen Mary University LondonBrain Tumour Research Centre, Faculty of Medicine and Dentistry, Blizard Institute, Queen Mary University LondonBrain Tumour Research Centre, Faculty of Medicine and Dentistry, Blizard Institute, Queen Mary University LondonGenome Centre, Faculty of Medicine and Dentistry, Blizard Institute, Queen Mary University LondonFaculty of Medicine and Dentistry, Blizard Institute, Queen Mary University LondonBrain Tumour Research Centre, Faculty of Medicine and Dentistry, Blizard Institute, Queen Mary University LondonAbstract Background Glioblastoma is the most common and aggressive malignant brain tumour in the adult population and its prognosis is dismal. The heterogeneous nature of the tumour, to which epigenetic dysregulation significantly contributes, is among the main therapeutic challenges of the disease. Results We have leveraged SYNGN, an experimental pipeline enabling the syngeneic comparison of glioblastoma stem cells and expanded potential stem cell (EPSC)-derived neural stem cells to identify regulatory features driven by chromatin remodelling specifically in glioblastoma stem cells. Conclusions We show epigenetic regulation of the expression of genes and related signalling pathways contributing to glioblastoma development. We also identify novel epigenetically regulated druggable target genes on a patient-specific level, including SMOX and GABBR2.https://doi.org/10.1186/s12915-025-02127-9GlioblastomaCell of originEpigeneticsChromatin remodellingDruggable targets |
| spellingShingle | Claire Vinel James Boot Weiwei Jin Nicola Pomella Alexandra Hadaway Charles Mein Nicolae Radu Zabet Silvia Marino Mapping chromatin remodelling in glioblastoma identifies epigenetic regulation of key molecular pathways and novel druggable targets BMC Biology Glioblastoma Cell of origin Epigenetics Chromatin remodelling Druggable targets |
| title | Mapping chromatin remodelling in glioblastoma identifies epigenetic regulation of key molecular pathways and novel druggable targets |
| title_full | Mapping chromatin remodelling in glioblastoma identifies epigenetic regulation of key molecular pathways and novel druggable targets |
| title_fullStr | Mapping chromatin remodelling in glioblastoma identifies epigenetic regulation of key molecular pathways and novel druggable targets |
| title_full_unstemmed | Mapping chromatin remodelling in glioblastoma identifies epigenetic regulation of key molecular pathways and novel druggable targets |
| title_short | Mapping chromatin remodelling in glioblastoma identifies epigenetic regulation of key molecular pathways and novel druggable targets |
| title_sort | mapping chromatin remodelling in glioblastoma identifies epigenetic regulation of key molecular pathways and novel druggable targets |
| topic | Glioblastoma Cell of origin Epigenetics Chromatin remodelling Druggable targets |
| url | https://doi.org/10.1186/s12915-025-02127-9 |
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