Synthesis and Anti-Inflammatory Activity of a Novel Series of Diphenyl-1,2,4-triazoles and Related Derivatives
In the present investigation we have synthesized a series of new 1-[3-(4-substitutedphenyl)-5-phenyl-4H-1,2,4-triazol-4-yl]urea and 1-[3-(4-substitutedphenyl)-5-phenyl-4H-1,2,4-triazol-4-yl]thiourea derivatives (4Ia - 4IId). The newly synthesised derivatives were characterized by using the data of I...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2012/278695 |
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| author | Swapna Cherala Harikiran Lingabathula Rama Ganta Srinivas Ampati Sarangapani Manda |
| author_facet | Swapna Cherala Harikiran Lingabathula Rama Ganta Srinivas Ampati Sarangapani Manda |
| author_sort | Swapna Cherala |
| collection | DOAJ |
| description | In the present investigation we have synthesized a series of new 1-[3-(4-substitutedphenyl)-5-phenyl-4H-1,2,4-triazol-4-yl]urea and 1-[3-(4-substitutedphenyl)-5-phenyl-4H-1,2,4-triazol-4-yl]thiourea derivatives (4Ia - 4IId). The newly synthesised derivatives were characterized by using the data of IR, 1H NMR and Mass Spectral analysis. Thus synthesised and characterized targetted compounds were further screened for their anti-inflammatory activity by using Carrageenan – induced paw edema rat model. Among all the newly synthesized derivatives, Compounds 4Ia-4Ic and Compounds 4IIa-4IId were reduced the inflammation very significantly (p<0.0001), thus these compounds showed promising anti-inflammatory activity and only one compound (4Id) showed moderate anti-inflammatory activity (p<0.05). |
| format | Article |
| id | doaj-art-8822781ae481421cadda367db194eb01 |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-8822781ae481421cadda367db194eb012025-02-03T01:10:10ZengWileyE-Journal of Chemistry0973-49452090-98102012-01-01942510251510.1155/2012/278695Synthesis and Anti-Inflammatory Activity of a Novel Series of Diphenyl-1,2,4-triazoles and Related DerivativesSwapna Cherala0Harikiran Lingabathula1Rama Ganta2Srinivas Ampati3Sarangapani Manda4Medicinal Chemistry Research Laboratory, University College of Pharmaceutical Sciences, Kakatiya Universtiy, Warangal, A.P-506 001, IndiaKakatiya Institute of Pharmaceutical Sciences, Pembarthy, Warangal, A.P-506371, IndiaKakatiya Institute of Pharmaceutical Sciences, Pembarthy, Warangal, A.P-506371, IndiaKakatiya Institute of Pharmaceutical Sciences, Pembarthy, Warangal, A.P-506371, IndiaMedicinal Chemistry Research Laboratory, University College of Pharmaceutical Sciences, Kakatiya Universtiy, Warangal, A.P-506 001, IndiaIn the present investigation we have synthesized a series of new 1-[3-(4-substitutedphenyl)-5-phenyl-4H-1,2,4-triazol-4-yl]urea and 1-[3-(4-substitutedphenyl)-5-phenyl-4H-1,2,4-triazol-4-yl]thiourea derivatives (4Ia - 4IId). The newly synthesised derivatives were characterized by using the data of IR, 1H NMR and Mass Spectral analysis. Thus synthesised and characterized targetted compounds were further screened for their anti-inflammatory activity by using Carrageenan – induced paw edema rat model. Among all the newly synthesized derivatives, Compounds 4Ia-4Ic and Compounds 4IIa-4IId were reduced the inflammation very significantly (p<0.0001), thus these compounds showed promising anti-inflammatory activity and only one compound (4Id) showed moderate anti-inflammatory activity (p<0.05).http://dx.doi.org/10.1155/2012/278695 |
| spellingShingle | Swapna Cherala Harikiran Lingabathula Rama Ganta Srinivas Ampati Sarangapani Manda Synthesis and Anti-Inflammatory Activity of a Novel Series of Diphenyl-1,2,4-triazoles and Related Derivatives E-Journal of Chemistry |
| title | Synthesis and Anti-Inflammatory Activity of a Novel Series of Diphenyl-1,2,4-triazoles and Related Derivatives |
| title_full | Synthesis and Anti-Inflammatory Activity of a Novel Series of Diphenyl-1,2,4-triazoles and Related Derivatives |
| title_fullStr | Synthesis and Anti-Inflammatory Activity of a Novel Series of Diphenyl-1,2,4-triazoles and Related Derivatives |
| title_full_unstemmed | Synthesis and Anti-Inflammatory Activity of a Novel Series of Diphenyl-1,2,4-triazoles and Related Derivatives |
| title_short | Synthesis and Anti-Inflammatory Activity of a Novel Series of Diphenyl-1,2,4-triazoles and Related Derivatives |
| title_sort | synthesis and anti inflammatory activity of a novel series of diphenyl 1 2 4 triazoles and related derivatives |
| url | http://dx.doi.org/10.1155/2012/278695 |
| work_keys_str_mv | AT swapnacherala synthesisandantiinflammatoryactivityofanovelseriesofdiphenyl124triazolesandrelatedderivatives AT harikiranlingabathula synthesisandantiinflammatoryactivityofanovelseriesofdiphenyl124triazolesandrelatedderivatives AT ramaganta synthesisandantiinflammatoryactivityofanovelseriesofdiphenyl124triazolesandrelatedderivatives AT srinivasampati synthesisandantiinflammatoryactivityofanovelseriesofdiphenyl124triazolesandrelatedderivatives AT sarangapanimanda synthesisandantiinflammatoryactivityofanovelseriesofdiphenyl124triazolesandrelatedderivatives |