Liver Function-Related Indicators and Risk of Gallstone Diseases—A Multicenter Study and a Systematic Review and Meta-Analysis
Results and conclusions: Totally, 369,931 subjects in CMPEC were included in the study. A total of 28 publications were incorporated into the systematic review and meta-analysis. The pooled analysis suggested that aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase...
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| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2024/9097892 |
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| _version_ | 1832544416010600448 |
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| author | Shiyi Li Pei Zhu Fangyuan Chen Wenqian Yu Linjun Xie Jing Xia Peng Jiao Ping Cui Chi Zhang Ye Bai Guoheng Jiang Hongyu Li Yanmei Lou Guangcan Li Xuefeng Shan Xin Wang |
| author_facet | Shiyi Li Pei Zhu Fangyuan Chen Wenqian Yu Linjun Xie Jing Xia Peng Jiao Ping Cui Chi Zhang Ye Bai Guoheng Jiang Hongyu Li Yanmei Lou Guangcan Li Xuefeng Shan Xin Wang |
| author_sort | Shiyi Li |
| collection | DOAJ |
| description | Results and conclusions: Totally, 369,931 subjects in CMPEC were included in the study. A total of 28 publications were incorporated into the systematic review and meta-analysis. The pooled analysis suggested that aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), total protein (TP), and low albumin (ALB) were positively associated with the risk of GSD. Meanwhile, GSD present to have higher AST, ALT, gamma-glutamyl transferase (GGT), total bilirubin (TBil), globulin (G), and ALP levels and relatively lower TP and ALB levels than the healthy participants. These results were consistent when stratified by the study design, geographic background, and study quality. Only the association between ALP and GSD risk was validated in the UKB cohort. This study suggests liver function indicators were associated with GSD risk. The results may provide the basis for exploring the etiology of GSD and may help clinicians identify high-risk subjects. |
| format | Article |
| id | doaj-art-881930fa2dbe43ee9af08ee4ad15a7ba |
| institution | Kabale University |
| issn | 1687-630X |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-881930fa2dbe43ee9af08ee4ad15a7ba2025-02-03T10:24:36ZengWileyGastroenterology Research and Practice1687-630X2024-01-01202410.1155/2024/9097892Liver Function-Related Indicators and Risk of Gallstone Diseases—A Multicenter Study and a Systematic Review and Meta-AnalysisShiyi Li0Pei Zhu1Fangyuan Chen2Wenqian Yu3Linjun Xie4Jing Xia5Peng Jiao6Ping Cui7Chi Zhang8Ye Bai9Guoheng Jiang10Hongyu Li11Yanmei Lou12Guangcan Li13Xuefeng Shan14Xin Wang15West China School of Public HealthDepartment of Vaccine Clinical Research InstituteMilitary Casualty Management DepartmentWest China School of Public HealthWest China School of Public HealthWest China School of Public HealthDepartment of Health ManagementDepartment of Public HealthDepartment of PreventionGene Diagnosis CenterWest China School of Public HealthWest China School of Public HealthDepartment of Health ManagementDepartment of PharmacyDepartment of PharmacyWest China School of Public HealthResults and conclusions: Totally, 369,931 subjects in CMPEC were included in the study. A total of 28 publications were incorporated into the systematic review and meta-analysis. The pooled analysis suggested that aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), total protein (TP), and low albumin (ALB) were positively associated with the risk of GSD. Meanwhile, GSD present to have higher AST, ALT, gamma-glutamyl transferase (GGT), total bilirubin (TBil), globulin (G), and ALP levels and relatively lower TP and ALB levels than the healthy participants. These results were consistent when stratified by the study design, geographic background, and study quality. Only the association between ALP and GSD risk was validated in the UKB cohort. This study suggests liver function indicators were associated with GSD risk. The results may provide the basis for exploring the etiology of GSD and may help clinicians identify high-risk subjects.http://dx.doi.org/10.1155/2024/9097892 |
| spellingShingle | Shiyi Li Pei Zhu Fangyuan Chen Wenqian Yu Linjun Xie Jing Xia Peng Jiao Ping Cui Chi Zhang Ye Bai Guoheng Jiang Hongyu Li Yanmei Lou Guangcan Li Xuefeng Shan Xin Wang Liver Function-Related Indicators and Risk of Gallstone Diseases—A Multicenter Study and a Systematic Review and Meta-Analysis Gastroenterology Research and Practice |
| title | Liver Function-Related Indicators and Risk of Gallstone Diseases—A Multicenter Study and a Systematic Review and Meta-Analysis |
| title_full | Liver Function-Related Indicators and Risk of Gallstone Diseases—A Multicenter Study and a Systematic Review and Meta-Analysis |
| title_fullStr | Liver Function-Related Indicators and Risk of Gallstone Diseases—A Multicenter Study and a Systematic Review and Meta-Analysis |
| title_full_unstemmed | Liver Function-Related Indicators and Risk of Gallstone Diseases—A Multicenter Study and a Systematic Review and Meta-Analysis |
| title_short | Liver Function-Related Indicators and Risk of Gallstone Diseases—A Multicenter Study and a Systematic Review and Meta-Analysis |
| title_sort | liver function related indicators and risk of gallstone diseases a multicenter study and a systematic review and meta analysis |
| url | http://dx.doi.org/10.1155/2024/9097892 |
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