High dynamic range capillary electrophoresis method for sensitive detection of low-frequency driver mutations

High dynamic range capillary electrophoresis method for sensitive detection of low-frequency driver mutations

Abstract Cancer genomics aims to personalize treatments by identifying genetic abnormalities in cancer cells. However, current analytical techniques face limitations in simplicity and cost-effectiveness. To address these issues, we developed an enhanced capillary gel electrophoresis (CE) sequencer u...

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Main Authors: Nobue Tamamura, Yoshihiko Hagiwara, Hirokazu Kato, Yusuke Ono, Kenji Takahashi, Kazuya Koyama, Hiroki Sato, Tetsuhiro Okada, Hidemasa Kawabata, Yu Ohtaki, Chiho Maeda, Miyuki Mori, Shin-ichi Chiba, Mishie Tanino, Kenzui Taniue, Takashi Anazawa, Ryoji Inaba, Yusuke Mizukami
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
HiDy
Capillary gel electrophoresis
Dynamic range
Low-frequency mutation
KRAS
Fragment analysis
Online Access:https://doi.org/10.1038/s41598-025-01884-5
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https://doi.org/10.1038/s41598-025-01884-5

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