Ergothioneine attenuates psoriasis symptoms through modulation of M1/M2 macrophage polarisation via the NF-κB/JAK-STAT3 pathway

Ergothioneine attenuates psoriasis symptoms through modulation of M1/M2 macrophage polarisation via the NF-κB/JAK-STAT3 pathway

IntroductionThe underlying cause of psoriasis, a chronic inflammatory skin condition driven by an immune response, remains a topic of active investigation and is not yet fully elucidated. Recent studies have revealed that ergothioneine, a small molecule sulfur-containing histidine derivative that ca...

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Bibliographic Details
Main Authors: Ang Li, Yanjie Liu, Peiling Yu, Zhiyuan Zhang, Tengxiao Huang, Hang Li, Songzhi Wu, Xiaoyu Rong, Wensheng Liao, Hongqiang Wang, Yanzheng Gao
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Pharmacology
Subjects:
psoriasis
ergothioneine
macrophage
anti-inflammatory
NF-κB
Jak-STAT3
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1521743/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1521743/full

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