Deep eutectic solvent enhances antibacterial activity of a modular lytic enzyme against Acinetobacter baumannii

Deep eutectic solvent enhances antibacterial activity of a modular lytic enzyme against Acinetobacter baumannii

Abstract In this study, we evaluated the combined effect between MLE-15, a modular lytic enzyme composed of four building blocks, and reline, a natural deep eutectic solvent. The bioinformatic analysis allowed us to determine the spatial architecture of MLE-15, whose components were bactericidal pep...

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Main Authors: Aleksandra Maria Kocot, Tomasz Swebocki, Karolina Ciemińska, Adrianna Łupkowska, Małgorzata Kapusta, Dennis Grimon, Ewa Laskowska, Anna-Karina Kaczorowska, Tadeusz Kaczorowski, Rabah Boukherroub, Yves Briers, Magdalena Plotka
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Modular lytic enzyme
Endolysin
Deep eutectic solvent
Synergism
Antibacterial effect
Biofilm
Online Access:https://doi.org/10.1038/s41598-024-80440-z
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https://doi.org/10.1038/s41598-024-80440-z

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