Chronic Disseminated Candidiasis Complicated by Immune Reconstitution Inflammatory Syndrome in Child with Acute Lymphoblastic Leukemia
Hepatosplenic candidiasis also known as chronic disseminated candidiasis is a rare manifestation of invasive fungal infection typically observed in patients with acute leukemia in prolonged, deep neutropenia. Immune reconstitution inflammatory syndrome (IRIS) is an inflammatory disorder triggered by...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2016/5960150 |
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| author | Olga Zając-Spychała Bogna Ukielska Katarzyna Jończyk-Potoczna Benigna Konatkowska Jacek Wachowiak |
| author_facet | Olga Zając-Spychała Bogna Ukielska Katarzyna Jończyk-Potoczna Benigna Konatkowska Jacek Wachowiak |
| author_sort | Olga Zając-Spychała |
| collection | DOAJ |
| description | Hepatosplenic candidiasis also known as chronic disseminated candidiasis is a rare manifestation of invasive fungal infection typically observed in patients with acute leukemia in prolonged, deep neutropenia. Immune reconstitution inflammatory syndrome (IRIS) is an inflammatory disorder triggered by rapid resolution of neutropenia. Diagnosis and treatment of IRIS are still challenging due to a variety of clinical symptoms, lack of certain diagnostic criteria, and no standards of treatment. The diagnosis of IRIS is even more difficult in patients with hematological malignancies complicated by “probable” invasive fungal infection, when fungal pathogen is still uncertain. We report a case of probable hepatic candidiasis in 4-year-old boy with acute lymphoblastic leukemia. Despite proper antifungal therapy, there was no clinical and radiological improvement, so diagnosis of Candida-related IRIS was made and corticosteroid therapy was added to antifungal treatment achieving prompt resolution of infection symptoms. |
| format | Article |
| id | doaj-art-87b5914cf7b845a4822c92d75b4cf1ae |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-87b5914cf7b845a4822c92d75b4cf1ae2025-02-03T06:13:52ZengWileyCase Reports in Hematology2090-65602090-65792016-01-01201610.1155/2016/59601505960150Chronic Disseminated Candidiasis Complicated by Immune Reconstitution Inflammatory Syndrome in Child with Acute Lymphoblastic LeukemiaOlga Zając-Spychała0Bogna Ukielska1Katarzyna Jończyk-Potoczna2Benigna Konatkowska3Jacek Wachowiak4Department of Pediatric Oncology, Hematology and Transplantology, University of Medical Sciences, Poznan, PolandDepartment of Pediatric Oncology, Hematology and Transplantology, University of Medical Sciences, Poznan, PolandDepartment of Pediatric Radiology, University of Medical Sciences, Poznan, PolandDepartment of Pediatric Oncology, Hematology and Transplantology, University of Medical Sciences, Poznan, PolandDepartment of Pediatric Oncology, Hematology and Transplantology, University of Medical Sciences, Poznan, PolandHepatosplenic candidiasis also known as chronic disseminated candidiasis is a rare manifestation of invasive fungal infection typically observed in patients with acute leukemia in prolonged, deep neutropenia. Immune reconstitution inflammatory syndrome (IRIS) is an inflammatory disorder triggered by rapid resolution of neutropenia. Diagnosis and treatment of IRIS are still challenging due to a variety of clinical symptoms, lack of certain diagnostic criteria, and no standards of treatment. The diagnosis of IRIS is even more difficult in patients with hematological malignancies complicated by “probable” invasive fungal infection, when fungal pathogen is still uncertain. We report a case of probable hepatic candidiasis in 4-year-old boy with acute lymphoblastic leukemia. Despite proper antifungal therapy, there was no clinical and radiological improvement, so diagnosis of Candida-related IRIS was made and corticosteroid therapy was added to antifungal treatment achieving prompt resolution of infection symptoms.http://dx.doi.org/10.1155/2016/5960150 |
| spellingShingle | Olga Zając-Spychała Bogna Ukielska Katarzyna Jończyk-Potoczna Benigna Konatkowska Jacek Wachowiak Chronic Disseminated Candidiasis Complicated by Immune Reconstitution Inflammatory Syndrome in Child with Acute Lymphoblastic Leukemia Case Reports in Hematology |
| title | Chronic Disseminated Candidiasis Complicated by Immune Reconstitution Inflammatory Syndrome in Child with Acute Lymphoblastic Leukemia |
| title_full | Chronic Disseminated Candidiasis Complicated by Immune Reconstitution Inflammatory Syndrome in Child with Acute Lymphoblastic Leukemia |
| title_fullStr | Chronic Disseminated Candidiasis Complicated by Immune Reconstitution Inflammatory Syndrome in Child with Acute Lymphoblastic Leukemia |
| title_full_unstemmed | Chronic Disseminated Candidiasis Complicated by Immune Reconstitution Inflammatory Syndrome in Child with Acute Lymphoblastic Leukemia |
| title_short | Chronic Disseminated Candidiasis Complicated by Immune Reconstitution Inflammatory Syndrome in Child with Acute Lymphoblastic Leukemia |
| title_sort | chronic disseminated candidiasis complicated by immune reconstitution inflammatory syndrome in child with acute lymphoblastic leukemia |
| url | http://dx.doi.org/10.1155/2016/5960150 |
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