Marchiafava-Bignami Disease in a Nonalcoholic Diabetic Patient
Marchiafava-Bignami disease (MBD) is a rare neurological disorder mostly seen in alcoholic and malnourished patients with a pathognomonic hallmark of corpus callosum demyelination. MBD in nonalcoholics without malnutrition has rarely been reported. We report a case of MBD in a diabetic patient, with...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | Case Reports in Neurological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2013/979383 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832551745650163712 |
|---|---|
| author | Sisira Yadala Jin Jun Luo |
| author_facet | Sisira Yadala Jin Jun Luo |
| author_sort | Sisira Yadala |
| collection | DOAJ |
| description | Marchiafava-Bignami disease (MBD) is a rare neurological disorder mostly seen in alcoholic and malnourished patients with a pathognomonic hallmark of corpus callosum demyelination. MBD in nonalcoholics without malnutrition has rarely been reported. We report a case of MBD in a diabetic patient, without alcoholism or malnutrition, caused by a wide range of glycemic level fluctuations. A 38-year-old man presented with sudden onset of alteration in speech and multiple falls in three days. Neurologic examination showed dysarthria, dysmetria, and ataxia but, otherwise, normal cranial nerves, motor and sensory functions, and tendon reflexes. Brain MRI showed symmetric abnormalities in the splenium of the corpus callosum. In addition, demyelination was also observed in bilateral posterior limbs of the internal capsule and brachium ponti. His symptoms significantly improved after stabilization and normalization of his plasma glucose level and administration of multivitamins and corticosteroids. The underlying pathophysiology of the development of MBD in our case is likely to be osmotic stress from a wide range of glycemic fluctuations causing structural and functional disturbance of oligodendrocytes, which may be reversible in its early stage. |
| format | Article |
| id | doaj-art-87a9c7a036024513aaf3e1e4f9561ea5 |
| institution | Kabale University |
| issn | 2090-6668 2090-6676 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Neurological Medicine |
| spelling | doaj-art-87a9c7a036024513aaf3e1e4f9561ea52025-02-03T06:00:34ZengWileyCase Reports in Neurological Medicine2090-66682090-66762013-01-01201310.1155/2013/979383979383Marchiafava-Bignami Disease in a Nonalcoholic Diabetic PatientSisira Yadala0Jin Jun Luo1Department of Neurology, Temple University School of Medicine, 3401 North Broad Street, Suite C525, Philadelphia, PA 19140, USADepartment of Neurology, Temple University School of Medicine, 3401 North Broad Street, Suite C525, Philadelphia, PA 19140, USAMarchiafava-Bignami disease (MBD) is a rare neurological disorder mostly seen in alcoholic and malnourished patients with a pathognomonic hallmark of corpus callosum demyelination. MBD in nonalcoholics without malnutrition has rarely been reported. We report a case of MBD in a diabetic patient, without alcoholism or malnutrition, caused by a wide range of glycemic level fluctuations. A 38-year-old man presented with sudden onset of alteration in speech and multiple falls in three days. Neurologic examination showed dysarthria, dysmetria, and ataxia but, otherwise, normal cranial nerves, motor and sensory functions, and tendon reflexes. Brain MRI showed symmetric abnormalities in the splenium of the corpus callosum. In addition, demyelination was also observed in bilateral posterior limbs of the internal capsule and brachium ponti. His symptoms significantly improved after stabilization and normalization of his plasma glucose level and administration of multivitamins and corticosteroids. The underlying pathophysiology of the development of MBD in our case is likely to be osmotic stress from a wide range of glycemic fluctuations causing structural and functional disturbance of oligodendrocytes, which may be reversible in its early stage.http://dx.doi.org/10.1155/2013/979383 |
| spellingShingle | Sisira Yadala Jin Jun Luo Marchiafava-Bignami Disease in a Nonalcoholic Diabetic Patient Case Reports in Neurological Medicine |
| title | Marchiafava-Bignami Disease in a Nonalcoholic Diabetic Patient |
| title_full | Marchiafava-Bignami Disease in a Nonalcoholic Diabetic Patient |
| title_fullStr | Marchiafava-Bignami Disease in a Nonalcoholic Diabetic Patient |
| title_full_unstemmed | Marchiafava-Bignami Disease in a Nonalcoholic Diabetic Patient |
| title_short | Marchiafava-Bignami Disease in a Nonalcoholic Diabetic Patient |
| title_sort | marchiafava bignami disease in a nonalcoholic diabetic patient |
| url | http://dx.doi.org/10.1155/2013/979383 |
| work_keys_str_mv | AT sisirayadala marchiafavabignamidiseaseinanonalcoholicdiabeticpatient AT jinjunluo marchiafavabignamidiseaseinanonalcoholicdiabeticpatient |