The Equivalence of Two Open Therapeutic Regimens of Cimetidine in the Treatment of Acute Duodenal Ulcer Disease: A Canadian Multicentre Trial
One hundred and four patients completed a multicentre study comparing the standard cimetidine regimen of 300 mg qid with cimetidine 600 mg bid in the treatment of acute duodenal ulcer. Both dosage regimens were effective in alleviating symptoms. At the two- and four-week assessments a significantly...
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| Format: | Article |
| Language: | English |
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Wiley
1990-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/1990/256258 |
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| author | H Navert AP Archambault IGM Cleator NB Hershfield EJ Prokipchuk ABR Thomson |
| author_facet | H Navert AP Archambault IGM Cleator NB Hershfield EJ Prokipchuk ABR Thomson |
| author_sort | H Navert |
| collection | DOAJ |
| description | One hundred and four patients completed a multicentre study
comparing the standard cimetidine regimen of 300 mg qid with cimetidine 600
mg bid in the treatment of acute duodenal ulcer. Both dosage regimens were
effective in alleviating symptoms. At the two- and four-week assessments a
significantly greater decrease in frequency, duration and severity of night time
pain was recorded in the 600 mg bid group (P<0.05). The healing rates were
equivalent in both treatment groups. After eight weeks of treatment, 96% of the
patients had healed in each treatment group. Cimetidine 600 mg bid may
represent a useful alternative therapeutic regimen to the standard 300 mg qid
dosage in patients with symptomatic acute duodenal ulcer disease. |
| format | Article |
| id | doaj-art-87a53348a5004a54ad9a2e2486ce97e8 |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 1990-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-87a53348a5004a54ad9a2e2486ce97e82025-02-03T01:09:39ZengWileyCanadian Journal of Gastroenterology0835-79001990-01-0142545810.1155/1990/256258The Equivalence of Two Open Therapeutic Regimens of Cimetidine in the Treatment of Acute Duodenal Ulcer Disease: A Canadian Multicentre TrialH Navert0AP Archambault1IGM Cleator2NB Hershfield3EJ Prokipchuk4ABR Thomson5Centre Hospitalier Universitaire, University of Sherbrooke, Sherbrooke, Quebec, CanadaCentre Hospitalier Maisonneuve-Rosemont, University of Montreal, Montreal, Quebec, CanadaSt Paul’s Hospital, University of British Columbia, Vancouver, British Columbia, CanadaFoothills Hospital, University of Calgary, Calgary, Alberta, CanadaSt Michael’s Hospital, University of Toronto, Toronto, Ontario, CanadaUniversity of Alberta Hospital, University of Alberta, Edmonton, Alberta, CanadaOne hundred and four patients completed a multicentre study comparing the standard cimetidine regimen of 300 mg qid with cimetidine 600 mg bid in the treatment of acute duodenal ulcer. Both dosage regimens were effective in alleviating symptoms. At the two- and four-week assessments a significantly greater decrease in frequency, duration and severity of night time pain was recorded in the 600 mg bid group (P<0.05). The healing rates were equivalent in both treatment groups. After eight weeks of treatment, 96% of the patients had healed in each treatment group. Cimetidine 600 mg bid may represent a useful alternative therapeutic regimen to the standard 300 mg qid dosage in patients with symptomatic acute duodenal ulcer disease.http://dx.doi.org/10.1155/1990/256258 |
| spellingShingle | H Navert AP Archambault IGM Cleator NB Hershfield EJ Prokipchuk ABR Thomson The Equivalence of Two Open Therapeutic Regimens of Cimetidine in the Treatment of Acute Duodenal Ulcer Disease: A Canadian Multicentre Trial Canadian Journal of Gastroenterology |
| title | The Equivalence of Two Open Therapeutic Regimens of Cimetidine in the Treatment of Acute Duodenal Ulcer Disease: A Canadian Multicentre Trial |
| title_full | The Equivalence of Two Open Therapeutic Regimens of Cimetidine in the Treatment of Acute Duodenal Ulcer Disease: A Canadian Multicentre Trial |
| title_fullStr | The Equivalence of Two Open Therapeutic Regimens of Cimetidine in the Treatment of Acute Duodenal Ulcer Disease: A Canadian Multicentre Trial |
| title_full_unstemmed | The Equivalence of Two Open Therapeutic Regimens of Cimetidine in the Treatment of Acute Duodenal Ulcer Disease: A Canadian Multicentre Trial |
| title_short | The Equivalence of Two Open Therapeutic Regimens of Cimetidine in the Treatment of Acute Duodenal Ulcer Disease: A Canadian Multicentre Trial |
| title_sort | equivalence of two open therapeutic regimens of cimetidine in the treatment of acute duodenal ulcer disease a canadian multicentre trial |
| url | http://dx.doi.org/10.1155/1990/256258 |
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