Therapeutic Potential of Ginger against Renal Injury Induced by Carbon Tetrachloride in Rats
The objective of this study was to evaluate the potential of successive ginger extracts (petroleum ether, chloroform, and ethanol) against nephrotoxicity induced by CCl4 in rats. The evaluation was done through measuring kidney antioxidant parameters: glutathione (GSH), lipid peroxides (LPO), and su...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/840421 |
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| author | Manal A. Hamed Sanaa A. Ali Nagy Saba El-Rigal |
| author_facet | Manal A. Hamed Sanaa A. Ali Nagy Saba El-Rigal |
| author_sort | Manal A. Hamed |
| collection | DOAJ |
| description | The objective of this study was to evaluate the potential of successive ginger extracts (petroleum ether, chloroform, and ethanol) against nephrotoxicity induced by CCl4 in rats. The evaluation was done through measuring kidney antioxidant parameters: glutathione (GSH), lipid peroxides (LPO), and superoxide dismutase (SOD). Renal function test: urea, creatinine and serum protein values, were also evaluated. The work was extended to examine tissue inflammatory mediators, prostaglandin-E2 (PGE2), collagen content and the kidney histopathology. Severe alterations in all biomarkers were observed after injury with CCl4. Treatment with ginger extracts resulted in markedly decreased levels of LPO, PGE2, collagen and kidney function tests, while increased levels of GSH, SOD and serum protein were observed. In conclusion, extracts of ginger, particularly the ethanol, resulted in an attractive candidate for the treatment of nephropathy induced by CCl4 through scavenging free radicals, improved kidney functions, inhibition of inflammatory mediators, and normalizing the kidney histopathological architecture. Further studies are required in order to identify the molecules responsible of the pharmacological activity. |
| format | Article |
| id | doaj-art-87a1be3e6daf4053ac6ef57a40d9ece6 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-87a1be3e6daf4053ac6ef57a40d9ece62025-02-03T01:11:35ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/840421840421Therapeutic Potential of Ginger against Renal Injury Induced by Carbon Tetrachloride in RatsManal A. Hamed0Sanaa A. Ali1Nagy Saba El-Rigal2Therapeutic Chemistry Department, National Research Center, Dokki 12311, Cairo, EgyptTherapeutic Chemistry Department, National Research Center, Dokki 12311, Cairo, EgyptTherapeutic Chemistry Department, National Research Center, Dokki 12311, Cairo, EgyptThe objective of this study was to evaluate the potential of successive ginger extracts (petroleum ether, chloroform, and ethanol) against nephrotoxicity induced by CCl4 in rats. The evaluation was done through measuring kidney antioxidant parameters: glutathione (GSH), lipid peroxides (LPO), and superoxide dismutase (SOD). Renal function test: urea, creatinine and serum protein values, were also evaluated. The work was extended to examine tissue inflammatory mediators, prostaglandin-E2 (PGE2), collagen content and the kidney histopathology. Severe alterations in all biomarkers were observed after injury with CCl4. Treatment with ginger extracts resulted in markedly decreased levels of LPO, PGE2, collagen and kidney function tests, while increased levels of GSH, SOD and serum protein were observed. In conclusion, extracts of ginger, particularly the ethanol, resulted in an attractive candidate for the treatment of nephropathy induced by CCl4 through scavenging free radicals, improved kidney functions, inhibition of inflammatory mediators, and normalizing the kidney histopathological architecture. Further studies are required in order to identify the molecules responsible of the pharmacological activity.http://dx.doi.org/10.1100/2012/840421 |
| spellingShingle | Manal A. Hamed Sanaa A. Ali Nagy Saba El-Rigal Therapeutic Potential of Ginger against Renal Injury Induced by Carbon Tetrachloride in Rats The Scientific World Journal |
| title | Therapeutic Potential of Ginger against Renal Injury Induced by Carbon Tetrachloride in Rats |
| title_full | Therapeutic Potential of Ginger against Renal Injury Induced by Carbon Tetrachloride in Rats |
| title_fullStr | Therapeutic Potential of Ginger against Renal Injury Induced by Carbon Tetrachloride in Rats |
| title_full_unstemmed | Therapeutic Potential of Ginger against Renal Injury Induced by Carbon Tetrachloride in Rats |
| title_short | Therapeutic Potential of Ginger against Renal Injury Induced by Carbon Tetrachloride in Rats |
| title_sort | therapeutic potential of ginger against renal injury induced by carbon tetrachloride in rats |
| url | http://dx.doi.org/10.1100/2012/840421 |
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