Ankle reflex and neurological symptom score: a primary level screening method for diabetic peripheral neuropathy
Herein, we aimed to develop an easily available and efficient screening method for diabetic peripheral neuropathy (DPN) suitable for primary care settings, emphasizing simplicity, speed, and accuracy. Nerve conduction studies were conducted on 214 patients with diabetes, encompassing the outcomes of...
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The Japan Endocrine Society
2024-02-01
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| Series: | Endocrine Journal |
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| Online Access: | https://www.jstage.jst.go.jp/article/endocrj/71/2/71_EJ23-0476/_html/-char/en |
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| author | Xueya Ma Mengyuan Li Hui Xie Ting Sun Liang Lu Sumei Li Yining Sun Zuchang Ma |
| author_facet | Xueya Ma Mengyuan Li Hui Xie Ting Sun Liang Lu Sumei Li Yining Sun Zuchang Ma |
| author_sort | Xueya Ma |
| collection | DOAJ |
| description | Herein, we aimed to develop an easily available and efficient screening method for diabetic peripheral neuropathy (DPN) suitable for primary care settings, emphasizing simplicity, speed, and accuracy. Nerve conduction studies were conducted on 214 patients with diabetes, encompassing the outcomes of five distinct assessments: diabetic neuropathy symptom (DNS), vibration perception threshold (VPT), and nerve screening. The diagnostic accuracy of the VPT and nerve screening was evaluated by comparing them with that of the nerve conduction study. To assess diagnostic efficacy, various combinations were examined, including DNS combined with VPT, pain, temperature, touch, and ankle reflex. The diagnostic performance of DNS was superior to that of the five neurological screening items and VPT, with sensitivity, specificity, and accuracy of 0.68, 0.81, and 0.73, respectively. Among the two combined methods, “DNS + ankle reflex” was identified as having the highest diagnostic value, with an area under the curve, a sensitivity, a specificity, and an accuracy of 0.81, 0.89, 0.70, and 0.80, respectively. Furthermore, a combination of “DNS + ankle reflex + touch + pain + VPT” achieved the best performance among the five combinations, with an area under the curve, sensitivity, specificity, and accuracy of 0.85, 0.93, 0.68, and 0.81, respectively. The combination of DNS, ankle reflex, touch, pain, and VPT methods showed the highest diagnostic value for DPN. However, considering factors including accuracy, time, and economic cost, we recommend using a simpler combination of DNS and ankle reflex for large-scale screening of patients with DPN. |
| format | Article |
| id | doaj-art-87a150524a4147ae8bb79873ef1eb859 |
| institution | Kabale University |
| issn | 1348-4540 |
| language | English |
| publishDate | 2024-02-01 |
| publisher | The Japan Endocrine Society |
| record_format | Article |
| series | Endocrine Journal |
| spelling | doaj-art-87a150524a4147ae8bb79873ef1eb8592025-01-22T06:33:21ZengThe Japan Endocrine SocietyEndocrine Journal1348-45402024-02-0171212913710.1507/endocrj.EJ23-0476endocrjAnkle reflex and neurological symptom score: a primary level screening method for diabetic peripheral neuropathyXueya Ma0Mengyuan Li1Hui Xie2Ting Sun3Liang Lu4Sumei Li5Yining Sun6Zuchang Ma7School of Nursing, Bengbu Medical College, Bengbu 233000, ChinaSchool of Nursing, Bengbu Medical College, Bengbu 233000, ChinaSchool of Nursing, Bengbu Medical College, Bengbu 233000, ChinaSchool of Nursing, Bengbu Medical College, Bengbu 233000, ChinaInstitute of Intelligent Machines, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, ChinaThe First Affiliated Hospital of University of Science and Technology of China, Hefei 230022, ChinaInstitute of Intelligent Machines, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, ChinaSchool of Nursing, Bengbu Medical College, Bengbu 233000, ChinaHerein, we aimed to develop an easily available and efficient screening method for diabetic peripheral neuropathy (DPN) suitable for primary care settings, emphasizing simplicity, speed, and accuracy. Nerve conduction studies were conducted on 214 patients with diabetes, encompassing the outcomes of five distinct assessments: diabetic neuropathy symptom (DNS), vibration perception threshold (VPT), and nerve screening. The diagnostic accuracy of the VPT and nerve screening was evaluated by comparing them with that of the nerve conduction study. To assess diagnostic efficacy, various combinations were examined, including DNS combined with VPT, pain, temperature, touch, and ankle reflex. The diagnostic performance of DNS was superior to that of the five neurological screening items and VPT, with sensitivity, specificity, and accuracy of 0.68, 0.81, and 0.73, respectively. Among the two combined methods, “DNS + ankle reflex” was identified as having the highest diagnostic value, with an area under the curve, a sensitivity, a specificity, and an accuracy of 0.81, 0.89, 0.70, and 0.80, respectively. Furthermore, a combination of “DNS + ankle reflex + touch + pain + VPT” achieved the best performance among the five combinations, with an area under the curve, sensitivity, specificity, and accuracy of 0.85, 0.93, 0.68, and 0.81, respectively. The combination of DNS, ankle reflex, touch, pain, and VPT methods showed the highest diagnostic value for DPN. However, considering factors including accuracy, time, and economic cost, we recommend using a simpler combination of DNS and ankle reflex for large-scale screening of patients with DPN.https://www.jstage.jst.go.jp/article/endocrj/71/2/71_EJ23-0476/_html/-char/endiabetic peripheral neuropathycombined diagnosisdiabetic neuropathy symptomankle reflexscreening |
| spellingShingle | Xueya Ma Mengyuan Li Hui Xie Ting Sun Liang Lu Sumei Li Yining Sun Zuchang Ma Ankle reflex and neurological symptom score: a primary level screening method for diabetic peripheral neuropathy Endocrine Journal diabetic peripheral neuropathy combined diagnosis diabetic neuropathy symptom ankle reflex screening |
| title | Ankle reflex and neurological symptom score: a primary level screening method for diabetic peripheral neuropathy |
| title_full | Ankle reflex and neurological symptom score: a primary level screening method for diabetic peripheral neuropathy |
| title_fullStr | Ankle reflex and neurological symptom score: a primary level screening method for diabetic peripheral neuropathy |
| title_full_unstemmed | Ankle reflex and neurological symptom score: a primary level screening method for diabetic peripheral neuropathy |
| title_short | Ankle reflex and neurological symptom score: a primary level screening method for diabetic peripheral neuropathy |
| title_sort | ankle reflex and neurological symptom score a primary level screening method for diabetic peripheral neuropathy |
| topic | diabetic peripheral neuropathy combined diagnosis diabetic neuropathy symptom ankle reflex screening |
| url | https://www.jstage.jst.go.jp/article/endocrj/71/2/71_EJ23-0476/_html/-char/en |
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