Identification of pyrimidine metabolism-based molecular subtypes and prognostic signature to predict immune landscape and guide clinical treatment in prostate cancer

Identification of pyrimidine metabolism-based molecular subtypes and prognostic signature to predict immune landscape and guide clinical treatment in prostate cancer

Background We previously described the enrichment of plasma exosome metabolites in CRPC, PCa, and TFC cohorts, and found significant differences in pyrimidine metabolites. The PMGs is associated with the clinical prognosis of several cancers, but its biological role in PCa is still unclear.Methods T...

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Main Authors: Yu-Zhong Yu, Xiao Xie, Mao-Ping Cai, Ya-Ying Hong, Yang-Zi Ren, Xi Kang, Hai-Chen Yan, Yang Xiong, Hong Chen, Xing-Cheng Wu, Dao-Sheng Luo, Shan-Chao Zhao
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Annals of Medicine
Subjects:
Pyrimidine metabolism
prognostic signature
immunity
thymidine kinase 1
prostate cancer
Online Access:https://www.tandfonline.com/doi/10.1080/07853890.2025.2449584
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https://www.tandfonline.com/doi/10.1080/07853890.2025.2449584

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