Epilepsy Treatment Outcome and Its Predictors among Ambulatory Patients with Epilepsy at Mizan-Tepi University Teaching Hospital, Southwest Ethiopia
Background. Epilepsy is among the most common neurological disorders which is highly treatable with currently available antiepileptic drugs at a reasonable price. In Ethiopia, despite a number of studies revealed high prevalence of epilepsy, little is known on predictors of poorly controlled seizure...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Neurology Research International |
| Online Access: | http://dx.doi.org/10.1155/2020/8109858 |
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| author | Ameha Zewudie Yitagesu Mamo Desalegn Feyissa Mohammed Yimam Gosaye Mekonen Ahmed Abdela |
| author_facet | Ameha Zewudie Yitagesu Mamo Desalegn Feyissa Mohammed Yimam Gosaye Mekonen Ahmed Abdela |
| author_sort | Ameha Zewudie |
| collection | DOAJ |
| description | Background. Epilepsy is among the most common neurological disorders which is highly treatable with currently available antiepileptic drugs at a reasonable price. In Ethiopia, despite a number of studies revealed high prevalence of epilepsy, little is known on predictors of poorly controlled seizures. Thus, the aim of this study was to assess epilepsy treatment outcome and its predictors among patients with epilepsy on follow-up at the ambulatory care unit of Mizan-Tepi University Teaching Hospital, Southwest Ethiopia. Methods. A hospital-based cross-sectional study involving patient interview and chart review was conducted from March 10 to April 10, 2018. Drug use patterns and sociodemographic data of the study participants were accustomed to descriptive statistics. Backward logistic regression analysis was done to identify predictors of poor seizure control. Statistical significance was considered at p value <0.05. Results. From a total of 143 studied patients with epilepsy, 60.8% had uncontrolled seizures. Monotherapy (79%) was commonly used for the treatment of seizures, of which phenobarbital was the most commonly utilized single anticonvulsant drug (62.9%). The majority (72.7%) of the patients had developed one or more antiepileptic-related adverse effects. Medium medication adherence (adjusted odds ratio (AOR) = 5.4; 95% CI = 1.52–19.23; p=0.009), poor medication adherence (AOR = 8.16; 95% CI = 3.04–21.90; p=0.001), head injury before seizure occurrence (AOR = 4.9; 95% CI = 1.25–19.27; p=0.02), and seizure attacks ≥4 episodes/week before AEDs initiation (AOR = 8.52; % CI = 2.41–13.45; p=0.001) were the predictors of uncontrolled seizure. Conclusions. Based on our findings, more than half of the patients with epilepsy had poorly controlled seizures. Nonadherence to antiepileptic drugs, high frequency of seizure attack before AEDs initiation, and history of a head injury before the occurrence of seizure were predictors of uncontrolled seizure. Patient medication adherence should be increased by the free access of antiepileptic drugs and attention should be given for the patients with a history of head injury and high frequency of seizure attacks before AEDs initiation. |
| format | Article |
| id | doaj-art-873259f8a3dc42ac9c24bdd35d8377d7 |
| institution | Kabale University |
| issn | 2090-1852 2090-1860 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
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| series | Neurology Research International |
| spelling | doaj-art-873259f8a3dc42ac9c24bdd35d8377d72025-02-03T05:49:55ZengWileyNeurology Research International2090-18522090-18602020-01-01202010.1155/2020/81098588109858Epilepsy Treatment Outcome and Its Predictors among Ambulatory Patients with Epilepsy at Mizan-Tepi University Teaching Hospital, Southwest EthiopiaAmeha Zewudie0Yitagesu Mamo1Desalegn Feyissa2Mohammed Yimam3Gosaye Mekonen4Ahmed Abdela5Department of Pharmacy, College of Medicine and Health Science, Mizan-Tepi University, Mizan-Aman, EthiopiaDepartment of Pharmacy, College of Medicine and Health Science, Mizan-Tepi University, Mizan-Aman, EthiopiaDepartment of Pharmacy, College of Medicine and Health Science, Mizan-Tepi University, Mizan-Aman, EthiopiaDepartment of Pharmacy, College of Medicine and Health Science, Mizan-Tepi University, Mizan-Aman, EthiopiaDepartment of Pharmacy, College of Medicine and Health Science, Ambo University, Ambo, EthiopiaDepartment of Pharmacy, College of Health Science, Bule-Hora University, Bule-Hora, EthiopiaBackground. Epilepsy is among the most common neurological disorders which is highly treatable with currently available antiepileptic drugs at a reasonable price. In Ethiopia, despite a number of studies revealed high prevalence of epilepsy, little is known on predictors of poorly controlled seizures. Thus, the aim of this study was to assess epilepsy treatment outcome and its predictors among patients with epilepsy on follow-up at the ambulatory care unit of Mizan-Tepi University Teaching Hospital, Southwest Ethiopia. Methods. A hospital-based cross-sectional study involving patient interview and chart review was conducted from March 10 to April 10, 2018. Drug use patterns and sociodemographic data of the study participants were accustomed to descriptive statistics. Backward logistic regression analysis was done to identify predictors of poor seizure control. Statistical significance was considered at p value <0.05. Results. From a total of 143 studied patients with epilepsy, 60.8% had uncontrolled seizures. Monotherapy (79%) was commonly used for the treatment of seizures, of which phenobarbital was the most commonly utilized single anticonvulsant drug (62.9%). The majority (72.7%) of the patients had developed one or more antiepileptic-related adverse effects. Medium medication adherence (adjusted odds ratio (AOR) = 5.4; 95% CI = 1.52–19.23; p=0.009), poor medication adherence (AOR = 8.16; 95% CI = 3.04–21.90; p=0.001), head injury before seizure occurrence (AOR = 4.9; 95% CI = 1.25–19.27; p=0.02), and seizure attacks ≥4 episodes/week before AEDs initiation (AOR = 8.52; % CI = 2.41–13.45; p=0.001) were the predictors of uncontrolled seizure. Conclusions. Based on our findings, more than half of the patients with epilepsy had poorly controlled seizures. Nonadherence to antiepileptic drugs, high frequency of seizure attack before AEDs initiation, and history of a head injury before the occurrence of seizure were predictors of uncontrolled seizure. Patient medication adherence should be increased by the free access of antiepileptic drugs and attention should be given for the patients with a history of head injury and high frequency of seizure attacks before AEDs initiation.http://dx.doi.org/10.1155/2020/8109858 |
| spellingShingle | Ameha Zewudie Yitagesu Mamo Desalegn Feyissa Mohammed Yimam Gosaye Mekonen Ahmed Abdela Epilepsy Treatment Outcome and Its Predictors among Ambulatory Patients with Epilepsy at Mizan-Tepi University Teaching Hospital, Southwest Ethiopia Neurology Research International |
| title | Epilepsy Treatment Outcome and Its Predictors among Ambulatory Patients with Epilepsy at Mizan-Tepi University Teaching Hospital, Southwest Ethiopia |
| title_full | Epilepsy Treatment Outcome and Its Predictors among Ambulatory Patients with Epilepsy at Mizan-Tepi University Teaching Hospital, Southwest Ethiopia |
| title_fullStr | Epilepsy Treatment Outcome and Its Predictors among Ambulatory Patients with Epilepsy at Mizan-Tepi University Teaching Hospital, Southwest Ethiopia |
| title_full_unstemmed | Epilepsy Treatment Outcome and Its Predictors among Ambulatory Patients with Epilepsy at Mizan-Tepi University Teaching Hospital, Southwest Ethiopia |
| title_short | Epilepsy Treatment Outcome and Its Predictors among Ambulatory Patients with Epilepsy at Mizan-Tepi University Teaching Hospital, Southwest Ethiopia |
| title_sort | epilepsy treatment outcome and its predictors among ambulatory patients with epilepsy at mizan tepi university teaching hospital southwest ethiopia |
| url | http://dx.doi.org/10.1155/2020/8109858 |
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