Phosphodiesterase Type 5 Inhibitors in Male Reproduction: Molecular Mechanisms and Clinical Implications for Fertility Management

Phosphodiesterase Type 5 Inhibitors in Male Reproduction: Molecular Mechanisms and Clinical Implications for Fertility Management

Phosphodiesterases, particularly the type 5 isoform (PDE5), have gained recognition as pivotal regulators of male reproductive physiology, exerting significant influence on testicular function, sperm maturation, and overall fertility potential. Over the past several decades, investigations have expa...

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Bibliographic Details
Main Authors: Aris Kaltsas, Fotios Dimitriadis, Athanasios Zachariou, Nikolaos Sofikitis, Michael Chrisofos
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Cells
Subjects:
phosphodiesterase (PDE)
PDE5 inhibitors
male reproduction
spermatogenesis
sperm motility
testicular physiology
Online Access:https://www.mdpi.com/2073-4409/14/2/120
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