Aberrant Regulation of Messenger RNA 3′-Untranslated Region in Human Cancer
The messenger RNA 3′-untranslated region (3′UTR) is emerging as critically important in regulating gene expression at posttranscriptional levels. The 3′UTR governs gene expression via orchestrated interactions between mRNA structural components (cis-elements) and specific trans-acting factors (RNA-b...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2007-01-01
|
| Series: | Cellular Oncology |
| Online Access: | http://dx.doi.org/10.1155/2007/586139 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832550289530421248 |
|---|---|
| author | Isabel López de Silanes María Paz Quesada Manel Esteller |
| author_facet | Isabel López de Silanes María Paz Quesada Manel Esteller |
| author_sort | Isabel López de Silanes |
| collection | DOAJ |
| description | The messenger RNA 3′-untranslated region (3′UTR) is emerging as critically important in regulating gene expression at posttranscriptional levels. The 3′UTR governs gene expression via orchestrated interactions between mRNA structural components (cis-elements) and specific trans-acting factors (RNA-binding proteins and non-coding RNAs). Alterations in any of these components can lead to disease. Here, we review the mutations in 3′UTR regulatory sequences as well as the aberrant levels, subcellular localization, and posttranslational modifications of trans-acting factors that can promote or enhance the malignant phenotype of cancer cells. A thorough understanding of these alterations and their impact upon 3′UTR-directed posttranscriptional gene regulation will uncover promising new targets for therapeutic intervention. |
| format | Article |
| id | doaj-art-86fd989ced224e0983d0ccef9762f40d |
| institution | Kabale University |
| issn | 1570-5870 1875-8606 |
| language | English |
| publishDate | 2007-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cellular Oncology |
| spelling | doaj-art-86fd989ced224e0983d0ccef9762f40d2025-02-03T06:07:09ZengWileyCellular Oncology1570-58701875-86062007-01-0129111710.1155/2007/586139Aberrant Regulation of Messenger RNA 3′-Untranslated Region in Human CancerIsabel López de Silanes0María Paz Quesada1Manel Esteller2Cancer Epigenetics Laboratory, Spanish National Cancer Centre (CNIO), 28029 Madrid, SpainCancer Epigenetics Laboratory, Spanish National Cancer Centre (CNIO), 28029 Madrid, SpainCancer Epigenetics Laboratory, Spanish National Cancer Centre (CNIO), 28029 Madrid, SpainThe messenger RNA 3′-untranslated region (3′UTR) is emerging as critically important in regulating gene expression at posttranscriptional levels. The 3′UTR governs gene expression via orchestrated interactions between mRNA structural components (cis-elements) and specific trans-acting factors (RNA-binding proteins and non-coding RNAs). Alterations in any of these components can lead to disease. Here, we review the mutations in 3′UTR regulatory sequences as well as the aberrant levels, subcellular localization, and posttranslational modifications of trans-acting factors that can promote or enhance the malignant phenotype of cancer cells. A thorough understanding of these alterations and their impact upon 3′UTR-directed posttranscriptional gene regulation will uncover promising new targets for therapeutic intervention.http://dx.doi.org/10.1155/2007/586139 |
| spellingShingle | Isabel López de Silanes María Paz Quesada Manel Esteller Aberrant Regulation of Messenger RNA 3′-Untranslated Region in Human Cancer Cellular Oncology |
| title | Aberrant Regulation of Messenger RNA 3′-Untranslated Region in Human Cancer |
| title_full | Aberrant Regulation of Messenger RNA 3′-Untranslated Region in Human Cancer |
| title_fullStr | Aberrant Regulation of Messenger RNA 3′-Untranslated Region in Human Cancer |
| title_full_unstemmed | Aberrant Regulation of Messenger RNA 3′-Untranslated Region in Human Cancer |
| title_short | Aberrant Regulation of Messenger RNA 3′-Untranslated Region in Human Cancer |
| title_sort | aberrant regulation of messenger rna 3 untranslated region in human cancer |
| url | http://dx.doi.org/10.1155/2007/586139 |
| work_keys_str_mv | AT isabellopezdesilanes aberrantregulationofmessengerrna3untranslatedregioninhumancancer AT mariapazquesada aberrantregulationofmessengerrna3untranslatedregioninhumancancer AT manelesteller aberrantregulationofmessengerrna3untranslatedregioninhumancancer |