Can antibodies be “vegan”? A guide through the maze of today’s antibody generation methods
There is no doubt that today’s life sciences would look very different without the availability of millions of research antibody products. Nevertheless, the use of antibody reagents that are poorly characterized has led to the publication of false or misleading results. The use of laboratory animals...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | mAbs |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/19420862.2024.2343499 |
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| author | Stefan Dübel |
| author_facet | Stefan Dübel |
| author_sort | Stefan Dübel |
| collection | DOAJ |
| description | There is no doubt that today’s life sciences would look very different without the availability of millions of research antibody products. Nevertheless, the use of antibody reagents that are poorly characterized has led to the publication of false or misleading results. The use of laboratory animals to produce research antibodies has also been criticized. Surprisingly, both problems can be addressed with the same technology. This review charts today’s maze of different antibody formats and the various methods for antibody production and their interconnections, ultimately concluding that sequence-defined recombinant antibodies offer a clear path to both improved quality of experimental data and reduced use of animals. |
| format | Article |
| id | doaj-art-86f5d6d3461e48e79af986cb8b1ea094 |
| institution | Kabale University |
| issn | 1942-0862 1942-0870 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | mAbs |
| spelling | doaj-art-86f5d6d3461e48e79af986cb8b1ea0942025-01-31T04:19:37ZengTaylor & Francis GroupmAbs1942-08621942-08702024-12-0116110.1080/19420862.2024.2343499Can antibodies be “vegan”? A guide through the maze of today’s antibody generation methodsStefan Dübel0Institute of Biochemistry, Biotechnology and Bioinformatics, Technische Universität Braunschweig, Braunschweig, GermanyThere is no doubt that today’s life sciences would look very different without the availability of millions of research antibody products. Nevertheless, the use of antibody reagents that are poorly characterized has led to the publication of false or misleading results. The use of laboratory animals to produce research antibodies has also been criticized. Surprisingly, both problems can be addressed with the same technology. This review charts today’s maze of different antibody formats and the various methods for antibody production and their interconnections, ultimately concluding that sequence-defined recombinant antibodies offer a clear path to both improved quality of experimental data and reduced use of animals.https://www.tandfonline.com/doi/10.1080/19420862.2024.2343499Monoclonal antibodiespolyclonal antibodiesrecombinant antibodiesmulticlonal antibodiesnon-animal derived antibodies, phage display, 3R, immunoglobulin, library, somatic hypermutation |
| spellingShingle | Stefan Dübel Can antibodies be “vegan”? A guide through the maze of today’s antibody generation methods mAbs Monoclonal antibodies polyclonal antibodies recombinant antibodies multiclonal antibodies non-animal derived antibodies, phage display, 3R, immunoglobulin, library, somatic hypermutation |
| title | Can antibodies be “vegan”? A guide through the maze of today’s antibody generation methods |
| title_full | Can antibodies be “vegan”? A guide through the maze of today’s antibody generation methods |
| title_fullStr | Can antibodies be “vegan”? A guide through the maze of today’s antibody generation methods |
| title_full_unstemmed | Can antibodies be “vegan”? A guide through the maze of today’s antibody generation methods |
| title_short | Can antibodies be “vegan”? A guide through the maze of today’s antibody generation methods |
| title_sort | can antibodies be vegan a guide through the maze of today s antibody generation methods |
| topic | Monoclonal antibodies polyclonal antibodies recombinant antibodies multiclonal antibodies non-animal derived antibodies, phage display, 3R, immunoglobulin, library, somatic hypermutation |
| url | https://www.tandfonline.com/doi/10.1080/19420862.2024.2343499 |
| work_keys_str_mv | AT stefandubel canantibodiesbeveganaguidethroughthemazeoftodaysantibodygenerationmethods |