Synthetic heparan sulfate mimics based on chitosan derivatives show broad-spectrum antiviral activity

Synthetic heparan sulfate mimics based on chitosan derivatives show broad-spectrum antiviral activity

Abstract Enveloped viruses enter cells by binding to receptors present on host cell membranes, which trigger internalization and membrane fusion. For many viruses, this either directly or indirectly involves interaction with membrane-anchored carbohydrates, such as heparan sulfate, providing a poten...

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Main Authors: Julia Revuelta, Luciana Rusu, Clara Frances-Gomez, Elena Trapero, Susana Iglesias, Eva Calvo Pinilla, Ana-Belén Blázquez, Alfonso Gutiérrez-Adán, Acsah Konuparamban, Oscar Moreno, María Gómez Martínez, Alicia Forcada-Nadal, María Luisa López-Redondo, Ana Isabel Avilés-Alía, IBV-Covid19-Pipeline, José Luis Llácer, Jordi Llop, Miguel Ángel Martín Acebes, Ron Geller, Alfonso Fernández-Mayoralas
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-07763-z
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https://doi.org/10.1038/s42003-025-07763-z

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