Adapted hepatitis C virus clone infects innate immunity-deficient mouse hepatocytes with minimal human HCV entry factors

Adapted hepatitis C virus clone infects innate immunity-deficient mouse hepatocytes with minimal human HCV entry factors

Background & Aims: Hepatitis C virus (HCV) has a narrow species tropism and cannot infect mice. To understand HCV species tropism and to develop better animal models, we adapted HCV to infect mouse cells deficient in innate immunity and with minimal human HCV host factors. Methods: HCV was a...

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Main Authors: Julie Ann Sheldon, Melina Winkler, Qinggong Yuan, Nicola Frericks, Richard John Phillip Brown, Csaba Miskey, Natascha Gödecke, Sara Behme, Katharina Rox, Giorgia Mysegades, Florian Vondran, Dagmar Wirth, Thomas Pietschmann
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:JHEP Reports
Subjects:
Adaptation
Species tropism
Replication
Molecular clone
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555925000047
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http://www.sciencedirect.com/science/article/pii/S2589555925000047

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