Role of Scavenger Receptors in Glia-Mediated Neuroinflammatory Response Associated with Alzheimer’s Disease
It is widely accepted that cells serving immune functions in the brain, namely, microglia and astrocytes, are important mediators of pathological phenomena observed in Alzheimer’s disease. However, it is unknown how these cells initiate the response that results in cognitive impairment and neuronal...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2013/895651 |
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| _version_ | 1832561027847290880 |
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| author | Francisca Cornejo Rommy von Bernhardi |
| author_facet | Francisca Cornejo Rommy von Bernhardi |
| author_sort | Francisca Cornejo |
| collection | DOAJ |
| description | It is widely accepted that cells serving immune functions in the brain, namely, microglia and astrocytes, are important mediators of pathological phenomena observed in Alzheimer’s disease. However, it is unknown how these cells initiate the response that results in cognitive impairment and neuronal degeneration. Here, we review the participation of the immune response mediated by glial cells in Alzheimer’s disease and the role played by scavenger receptors in the development of this pathology, focusing on the relevance of class A scavenger receptor (SR-A) for Aβ clearance and inflammatory activation of glial cell, and as a potential target for Alzheimer’s disease therapy. |
| format | Article |
| id | doaj-art-86b67a4e1fca461e895472d39f821a6e |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-86b67a4e1fca461e895472d39f821a6e2025-02-03T01:26:12ZengWileyMediators of Inflammation0962-93511466-18612013-01-01201310.1155/2013/895651895651Role of Scavenger Receptors in Glia-Mediated Neuroinflammatory Response Associated with Alzheimer’s DiseaseFrancisca Cornejo0Rommy von Bernhardi1Laboratorio de Neurociencias, Departamento de Neurología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Marcoleta, 391 Santiago, ChileLaboratorio de Neurociencias, Departamento de Neurología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Marcoleta, 391 Santiago, ChileIt is widely accepted that cells serving immune functions in the brain, namely, microglia and astrocytes, are important mediators of pathological phenomena observed in Alzheimer’s disease. However, it is unknown how these cells initiate the response that results in cognitive impairment and neuronal degeneration. Here, we review the participation of the immune response mediated by glial cells in Alzheimer’s disease and the role played by scavenger receptors in the development of this pathology, focusing on the relevance of class A scavenger receptor (SR-A) for Aβ clearance and inflammatory activation of glial cell, and as a potential target for Alzheimer’s disease therapy.http://dx.doi.org/10.1155/2013/895651 |
| spellingShingle | Francisca Cornejo Rommy von Bernhardi Role of Scavenger Receptors in Glia-Mediated Neuroinflammatory Response Associated with Alzheimer’s Disease Mediators of Inflammation |
| title | Role of Scavenger Receptors in Glia-Mediated Neuroinflammatory Response Associated with Alzheimer’s Disease |
| title_full | Role of Scavenger Receptors in Glia-Mediated Neuroinflammatory Response Associated with Alzheimer’s Disease |
| title_fullStr | Role of Scavenger Receptors in Glia-Mediated Neuroinflammatory Response Associated with Alzheimer’s Disease |
| title_full_unstemmed | Role of Scavenger Receptors in Glia-Mediated Neuroinflammatory Response Associated with Alzheimer’s Disease |
| title_short | Role of Scavenger Receptors in Glia-Mediated Neuroinflammatory Response Associated with Alzheimer’s Disease |
| title_sort | role of scavenger receptors in glia mediated neuroinflammatory response associated with alzheimer s disease |
| url | http://dx.doi.org/10.1155/2013/895651 |
| work_keys_str_mv | AT franciscacornejo roleofscavengerreceptorsingliamediatedneuroinflammatoryresponseassociatedwithalzheimersdisease AT rommyvonbernhardi roleofscavengerreceptorsingliamediatedneuroinflammatoryresponseassociatedwithalzheimersdisease |