Hematopoietic Stem Cell Function in a Murine Model of Sickle Cell Disease

Hematopoietic Stem Cell Function in a Murine Model of Sickle Cell Disease

Previous studies have shown that the sickle environment is highly enriched for reactive oxygen species (ROS). We examined the oxidative effects of sickle cell disease on hematopoietic stem cell function in a sickle mouse model. In vitro colony-forming assays showed a significant decrease in progenit...

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Bibliographic Details
Main Authors: Elisabeth H. Javazon, Mohamed Radhi, Bagirath Gangadharan, Jennifer Perry, David R. Archer
Format: Article
Language:English
Published: Wiley 2012-01-01
Series:Anemia
Online Access:http://dx.doi.org/10.1155/2012/387385
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