EZH2 inhibition mitigates HIV immune evasion, reduces reservoir formation, and promotes skewing of CD8+ T cells toward less-exhausted phenotypes

EZH2 inhibition mitigates HIV immune evasion, reduces reservoir formation, and promotes skewing of CD8+ T cells toward less-exhausted phenotypes

Summary: Persistent HIV reservoirs in CD4+ T cells pose a barrier to curing HIV infection. We identify overexpression of enhancer of zeste homolog 2 (EZH2) in HIV-infected CD4+ T cells that survive cytotoxic T lymphocyte (CTL) exposure, suggesting a mechanism of CTL resistance. Inhibition of EZH2 wi...

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Main Authors: Andrea Gramatica, Itzayana G. Miller, Adam R. Ward, Farzana Khan, Tyler J. Kemmer, Jared Weiler, Tan Thinh Huynh, Paul Zumbo, Andrew P. Kurland, Louise Leyre, Yanqin Ren, Thais Klevorn, Dennis C. Copertino, Uchenna Chukwukere, Callie Levinger, Thomas R. Dilling, Noemi Linden, Nathan L. Board, Emma Falling Iversen, Sandra Terry, Talia M. Mota, Seden Bedir, Kiera L. Clayton, Alberto Bosque, Lynsay MacLaren Ehui, Colin Kovacs, Doron Betel, Jeffry R. Johnson, Mirko Paiardini, Ali Danesh, R. Brad Jones
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Cell Reports
Subjects:
CP: Immunology
CP: Microbiology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725004231
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