Botulinum toxin: mechanisms of action Toxina botulínica: mecanismos de ação

Botulinum toxin: mechanisms of action Toxina botulínica: mecanismos de ação

This review describes therapeutically relevant mechanisms of action of botulinum toxin (BT). BT's molecular mode of action includes extracellular binding to glycoproteine structures on cholinergic nerve terminals and intracellular blockade of the acetylcholine secretion. BT affects the spinal s...

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Bibliographic Details
Main Authors: Dirk Dressler, Fereshte Adib Saberi, Egberto Reis Barbosa
Format: Article
Language:English
Published: Thieme Revinter Publicações 2005-03-01
Series:Arquivos de Neuro-Psiquiatria
Subjects:
toxina botulínica
mecanismos de ação
acetilcolina
fusos musculares
reflexo de estiramento
músculos lisos
glândulas exócrinas
transporte axonal retrógrado
barreira hematoencefálica
substância P
botulinum toxin
mechanisms of action
acetylcholine
muscle spindles
stretch reflex
smooth muscles
exocrine glands
retrograde axonal transport
blood-brain-barrier
substance P
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2005000100035
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