Okra juice used for rapid wound healing through its bioadhesive and antioxidant capabilities
Rapid wound healing is of great importance as it plays a crucial role in the body's response to injury or trauma. Biological adhesives are generally easy to apply, allowing for quick and efficient wound closure. In this study, we develop a natural biological adhesive derived from okra juice thr...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-04-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006425000535 |
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| author | Biao Zhang Yuanqiang Li Kaijie Wu Liqi Wei Yining Chen Yuan Zhang Yiping Ren Tianshu Zou Pengcheng Yu Hongxia Ma Rui Chen Xin Liu Yan Cheng |
| author_facet | Biao Zhang Yuanqiang Li Kaijie Wu Liqi Wei Yining Chen Yuan Zhang Yiping Ren Tianshu Zou Pengcheng Yu Hongxia Ma Rui Chen Xin Liu Yan Cheng |
| author_sort | Biao Zhang |
| collection | DOAJ |
| description | Rapid wound healing is of great importance as it plays a crucial role in the body's response to injury or trauma. Biological adhesives are generally easy to apply, allowing for quick and efficient wound closure. In this study, we develop a natural biological adhesive derived from okra juice through a simple and environmentally friendly producing process. The strongest adhesion ability of this bioadhesive to wet tissue was 5.51 kPa, the ability to inhibit 2,2-diphenyl-1-(2,4,6-trinitrophenyl) hydrazyl radical, superoxide radical, hydroxyl radical, and hydrogen peroxide was 56.58 %, 49.94 %, 53.86 %, and 52.89 %, respectively, and the ability to promote cell proliferation was 181.46 %. The levels of pro-inflammatory tumor necrosis factor alpha (33.17 %) and Interleukin-6 (46.73 %) were significantly reduced. Both in vitro and in vivo evaluations indicate that it can effectively accelerate the healing process by sealing the wound, improving epithelial regeneration and angiogenesis, and alleviating inflammation. In addition, it has improved biocompatibility compared to commercial medical glue. Based on the favorable properties of the natural source, simple production process, and inherent nontoxicity, it shows potential as a medical bioadhesive for surgical procedures and emergency wound treatment. |
| format | Article |
| id | doaj-art-86692f3c266a4a45bb65ec41d5fba6be |
| institution | Kabale University |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-86692f3c266a4a45bb65ec41d5fba6be2025-01-18T05:05:08ZengElsevierMaterials Today Bio2590-00642025-04-0131101495Okra juice used for rapid wound healing through its bioadhesive and antioxidant capabilitiesBiao Zhang0Yuanqiang Li1Kaijie Wu2Liqi Wei3Yining Chen4Yuan Zhang5Yiping Ren6Tianshu Zou7Pengcheng Yu8Hongxia Ma9Rui Chen10Xin Liu11Yan Cheng12Engineering Research Center of Bioreactor and Pharmaceutical Development, Ministry of Education, College of Life Science, Jilin Agricultural University, Changchun, 130118, PR ChinaEngineering Research Center of Bioreactor and Pharmaceutical Development, Ministry of Education, College of Life Science, Jilin Agricultural University, Changchun, 130118, PR ChinaEngineering Research Center of Bioreactor and Pharmaceutical Development, Ministry of Education, College of Life Science, Jilin Agricultural University, Changchun, 130118, PR ChinaEngineering Research Center of Bioreactor and Pharmaceutical Development, Ministry of Education, College of Life Science, Jilin Agricultural University, Changchun, 130118, PR ChinaEngineering Research Center of Bioreactor and Pharmaceutical Development, Ministry of Education, College of Life Science, Jilin Agricultural University, Changchun, 130118, PR ChinaEngineering Research Center of Bioreactor and Pharmaceutical Development, Ministry of Education, College of Life Science, Jilin Agricultural University, Changchun, 130118, PR ChinaEngineering Research Center of Bioreactor and Pharmaceutical Development, Ministry of Education, College of Life Science, Jilin Agricultural University, Changchun, 130118, PR ChinaEngineering Research Center of Bioreactor and Pharmaceutical Development, Ministry of Education, College of Life Science, Jilin Agricultural University, Changchun, 130118, PR ChinaJilin Provincial Key Laboratory of Human Health Status Identification and Function Enhancement, School of Materials Science and Engineering, Changchun University, Changchun, 130022, PR ChinaEngineering Research Center of Bioreactor and Pharmaceutical Development, Ministry of Education, College of Life Science, Jilin Agricultural University, Changchun, 130118, PR ChinaJilin Provincial Key Laboratory of Human Health Status Identification and Function Enhancement, School of Materials Science and Engineering, Changchun University, Changchun, 130022, PR China; Corresponding author.Engineering Research Center of Bioreactor and Pharmaceutical Development, Ministry of Education, College of Life Science, Jilin Agricultural University, Changchun, 130118, PR China; Corresponding author.Engineering Research Center of Bioreactor and Pharmaceutical Development, Ministry of Education, College of Life Science, Jilin Agricultural University, Changchun, 130118, PR China; Corresponding author.Rapid wound healing is of great importance as it plays a crucial role in the body's response to injury or trauma. Biological adhesives are generally easy to apply, allowing for quick and efficient wound closure. In this study, we develop a natural biological adhesive derived from okra juice through a simple and environmentally friendly producing process. The strongest adhesion ability of this bioadhesive to wet tissue was 5.51 kPa, the ability to inhibit 2,2-diphenyl-1-(2,4,6-trinitrophenyl) hydrazyl radical, superoxide radical, hydroxyl radical, and hydrogen peroxide was 56.58 %, 49.94 %, 53.86 %, and 52.89 %, respectively, and the ability to promote cell proliferation was 181.46 %. The levels of pro-inflammatory tumor necrosis factor alpha (33.17 %) and Interleukin-6 (46.73 %) were significantly reduced. Both in vitro and in vivo evaluations indicate that it can effectively accelerate the healing process by sealing the wound, improving epithelial regeneration and angiogenesis, and alleviating inflammation. In addition, it has improved biocompatibility compared to commercial medical glue. Based on the favorable properties of the natural source, simple production process, and inherent nontoxicity, it shows potential as a medical bioadhesive for surgical procedures and emergency wound treatment.http://www.sciencedirect.com/science/article/pii/S2590006425000535OkraAntioxidantWound sealingBioadhesive |
| spellingShingle | Biao Zhang Yuanqiang Li Kaijie Wu Liqi Wei Yining Chen Yuan Zhang Yiping Ren Tianshu Zou Pengcheng Yu Hongxia Ma Rui Chen Xin Liu Yan Cheng Okra juice used for rapid wound healing through its bioadhesive and antioxidant capabilities Materials Today Bio Okra Antioxidant Wound sealing Bioadhesive |
| title | Okra juice used for rapid wound healing through its bioadhesive and antioxidant capabilities |
| title_full | Okra juice used for rapid wound healing through its bioadhesive and antioxidant capabilities |
| title_fullStr | Okra juice used for rapid wound healing through its bioadhesive and antioxidant capabilities |
| title_full_unstemmed | Okra juice used for rapid wound healing through its bioadhesive and antioxidant capabilities |
| title_short | Okra juice used for rapid wound healing through its bioadhesive and antioxidant capabilities |
| title_sort | okra juice used for rapid wound healing through its bioadhesive and antioxidant capabilities |
| topic | Okra Antioxidant Wound sealing Bioadhesive |
| url | http://www.sciencedirect.com/science/article/pii/S2590006425000535 |
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