X-Ray Computed Tomography: Semiautomated Volumetric Analysis of Late-Stage Lung Tumors as a Basis for Response Assessments
Background. This study presents a semiautomated approach for volumetric analysis of lung tumors and evaluates the feasibility of using volumes as an alternative to line lengths as a basis for response evaluation criteria in solid tumors (RECIST). The overall goal for the implementation was to accura...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | International Journal of Biomedical Imaging |
| Online Access: | http://dx.doi.org/10.1155/2011/361589 |
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| author | C. Bendtsen M. Kietzmann R. Korn P. D. Mozley G. Schmidt G. Binnig |
| author_facet | C. Bendtsen M. Kietzmann R. Korn P. D. Mozley G. Schmidt G. Binnig |
| author_sort | C. Bendtsen |
| collection | DOAJ |
| description | Background. This study presents a semiautomated approach for volumetric analysis of lung tumors and evaluates the feasibility of using volumes as an alternative to line lengths as a basis for response evaluation criteria in solid tumors (RECIST). The overall goal for the implementation was to accurately, precisely, and efficiently enable the analyses of lesions in the lung under the guidance of an operator. Methods. An anthropomorphic phantom with embedded model masses and 71 time points in 10 clinical cases with advanced lung cancer was analyzed using a semi-automated workflow. The implementation was done using the Cognition Network Technology. Results. Analysis of the phantom showed an average accuracy of 97%. The analyses of the clinical cases showed both intra- and interreader variabilities of approximately 5% on average with an upper 95% confidence interval of 14% and 19%, respectively. Compared to line lengths, the use of volumes clearly shows enhanced sensitivity with respect to determining response to therapy. Conclusions. It is feasible to perform volumetric analysis efficiently with high accuracy and low variability, even in patients with late-stage cancer who have complex lesions. |
| format | Article |
| id | doaj-art-865ecd0f059949948ec8b6295ea22d0d |
| institution | Kabale University |
| issn | 1687-4188 1687-4196 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Biomedical Imaging |
| spelling | doaj-art-865ecd0f059949948ec8b6295ea22d0d2025-02-03T01:07:32ZengWileyInternational Journal of Biomedical Imaging1687-41881687-41962011-01-01201110.1155/2011/361589361589X-Ray Computed Tomography: Semiautomated Volumetric Analysis of Late-Stage Lung Tumors as a Basis for Response AssessmentsC. Bendtsen0M. Kietzmann1R. Korn2P. D. Mozley3G. Schmidt4G. Binnig5DECS, AstraZeneca, 50S27 Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG, UKDefiniens AG, Trappentreustraße 1, 80339 München, GermanyDefiniens AG, Trappentreustraße 1, 80339 München, GermanyDepartment of Imaging, Merck Research Laboratories, 770 Sumneytown Pike, WP42-305, West Point, PA 19486-0004, USADefiniens AG, Trappentreustraße 1, 80339 München, GermanyDefiniens AG, Trappentreustraße 1, 80339 München, GermanyBackground. This study presents a semiautomated approach for volumetric analysis of lung tumors and evaluates the feasibility of using volumes as an alternative to line lengths as a basis for response evaluation criteria in solid tumors (RECIST). The overall goal for the implementation was to accurately, precisely, and efficiently enable the analyses of lesions in the lung under the guidance of an operator. Methods. An anthropomorphic phantom with embedded model masses and 71 time points in 10 clinical cases with advanced lung cancer was analyzed using a semi-automated workflow. The implementation was done using the Cognition Network Technology. Results. Analysis of the phantom showed an average accuracy of 97%. The analyses of the clinical cases showed both intra- and interreader variabilities of approximately 5% on average with an upper 95% confidence interval of 14% and 19%, respectively. Compared to line lengths, the use of volumes clearly shows enhanced sensitivity with respect to determining response to therapy. Conclusions. It is feasible to perform volumetric analysis efficiently with high accuracy and low variability, even in patients with late-stage cancer who have complex lesions.http://dx.doi.org/10.1155/2011/361589 |
| spellingShingle | C. Bendtsen M. Kietzmann R. Korn P. D. Mozley G. Schmidt G. Binnig X-Ray Computed Tomography: Semiautomated Volumetric Analysis of Late-Stage Lung Tumors as a Basis for Response Assessments International Journal of Biomedical Imaging |
| title | X-Ray Computed Tomography: Semiautomated Volumetric Analysis of Late-Stage Lung Tumors as a Basis for Response Assessments |
| title_full | X-Ray Computed Tomography: Semiautomated Volumetric Analysis of Late-Stage Lung Tumors as a Basis for Response Assessments |
| title_fullStr | X-Ray Computed Tomography: Semiautomated Volumetric Analysis of Late-Stage Lung Tumors as a Basis for Response Assessments |
| title_full_unstemmed | X-Ray Computed Tomography: Semiautomated Volumetric Analysis of Late-Stage Lung Tumors as a Basis for Response Assessments |
| title_short | X-Ray Computed Tomography: Semiautomated Volumetric Analysis of Late-Stage Lung Tumors as a Basis for Response Assessments |
| title_sort | x ray computed tomography semiautomated volumetric analysis of late stage lung tumors as a basis for response assessments |
| url | http://dx.doi.org/10.1155/2011/361589 |
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