Role of periodontal ligament fibroblasts in periodontitis: pathological mechanisms and therapeutic potential
Abstract Periodontal ligament fibroblasts (PDLFs) play a crucial role in the etiology of periodontitis and periodontal tissue regeneration. In healthy periodontal tissues, PDLFs maintain the homeostasis of periodontal soft and hard tissues as well as the local immune microenvironment. PDLFs also hav...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-12-01
|
| Series: | Journal of Translational Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12967-024-05944-8 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832571388118958080 |
|---|---|
| author | Yijie Huang Ying Tang Ruiqi Zhang Xiao Wu Li Yan Xiling Chen Qianqi Wu Yiyan Chen Yingtao Lv Yuan Su |
| author_facet | Yijie Huang Ying Tang Ruiqi Zhang Xiao Wu Li Yan Xiling Chen Qianqi Wu Yiyan Chen Yingtao Lv Yuan Su |
| author_sort | Yijie Huang |
| collection | DOAJ |
| description | Abstract Periodontal ligament fibroblasts (PDLFs) play a crucial role in the etiology of periodontitis and periodontal tissue regeneration. In healthy periodontal tissues, PDLFs maintain the homeostasis of periodontal soft and hard tissues as well as the local immune microenvironment. PDLFs also have the potential for multidirectional transdifferentiation and are involved in periodontal tissue regeneration. On the other hand, PDLFs can become dysfunctional and acquire an inflammatory phenotype to secret various inflammatory cytokines when affected by pathological factors. These cytokines further trigger immune and inflammatory events, and lead to destruction of periodontal soft and hard tissues as well as damage to the regenerative potential of PDLFs. This review summarizes the physiological functions of PDLFs. Meanwhile, this review also highlights recent insights into the pathological mechanisms driving the development of periodontitis through dysfunctional PDLFs and the negative impact on periodontal tissue regeneration. Additionally, this paper summarizes strategies for targeting PDLFs to treat periodontitis, involving blocking multiple stages of the inflammatory response induced by PDLFs and promoting the multidirectional transdifferentiation of PDLFs. Future research directions are proposed to address important questions that have not yet been answered in this field. This article provides a reference for understanding the important role of PDLFs in the pathological mechanisms of periodontitis and for developing new strategies for targeting PDLFs in periodontitis treatment. Graphical Abstract |
| format | Article |
| id | doaj-art-864f880876c54fc4abefb64e8ea1d4f0 |
| institution | Kabale University |
| issn | 1479-5876 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj-art-864f880876c54fc4abefb64e8ea1d4f02025-02-02T12:40:17ZengBMCJournal of Translational Medicine1479-58762024-12-0122111710.1186/s12967-024-05944-8Role of periodontal ligament fibroblasts in periodontitis: pathological mechanisms and therapeutic potentialYijie Huang0Ying Tang1Ruiqi Zhang2Xiao Wu3Li Yan4Xiling Chen5Qianqi Wu6Yiyan Chen7Yingtao Lv8Yuan Su9Stomatology Center, Shunde Hospital, Southern Medical University (The First People’s Hospital of Shunde)Department of Prosthodontics, Huangpu District Dental Disease Prevention and Treatment InstituteStomatology Center, Shunde Hospital, Southern Medical University (The First People’s Hospital of Shunde)Stomatology Center, Shunde Hospital, Southern Medical University (The First People’s Hospital of Shunde)Stomatology Center, Shunde Hospital, Southern Medical University (The First People’s Hospital of Shunde)Stomatology Center, Shunde Hospital, Southern Medical University (The First People’s Hospital of Shunde)Stomatology Center, Shunde Hospital, Southern Medical University (The First People’s Hospital of Shunde)Stomatology Center, Shunde Hospital, Southern Medical University (The First People’s Hospital of Shunde)Department of Prosthodontics, Stomatological Hospital, Southern Medical UniversityStomatology Center, Shunde Hospital, Southern Medical University (The First People’s Hospital of Shunde)Abstract Periodontal ligament fibroblasts (PDLFs) play a crucial role in the etiology of periodontitis and periodontal tissue regeneration. In healthy periodontal tissues, PDLFs maintain the homeostasis of periodontal soft and hard tissues as well as the local immune microenvironment. PDLFs also have the potential for multidirectional transdifferentiation and are involved in periodontal tissue regeneration. On the other hand, PDLFs can become dysfunctional and acquire an inflammatory phenotype to secret various inflammatory cytokines when affected by pathological factors. These cytokines further trigger immune and inflammatory events, and lead to destruction of periodontal soft and hard tissues as well as damage to the regenerative potential of PDLFs. This review summarizes the physiological functions of PDLFs. Meanwhile, this review also highlights recent insights into the pathological mechanisms driving the development of periodontitis through dysfunctional PDLFs and the negative impact on periodontal tissue regeneration. Additionally, this paper summarizes strategies for targeting PDLFs to treat periodontitis, involving blocking multiple stages of the inflammatory response induced by PDLFs and promoting the multidirectional transdifferentiation of PDLFs. Future research directions are proposed to address important questions that have not yet been answered in this field. This article provides a reference for understanding the important role of PDLFs in the pathological mechanisms of periodontitis and for developing new strategies for targeting PDLFs in periodontitis treatment. Graphical Abstracthttps://doi.org/10.1186/s12967-024-05944-8Periodontal Ligament FibroblastsPeriodontitisPathological MechanismsRegeneration of periodontal tissue |
| spellingShingle | Yijie Huang Ying Tang Ruiqi Zhang Xiao Wu Li Yan Xiling Chen Qianqi Wu Yiyan Chen Yingtao Lv Yuan Su Role of periodontal ligament fibroblasts in periodontitis: pathological mechanisms and therapeutic potential Journal of Translational Medicine Periodontal Ligament Fibroblasts Periodontitis Pathological Mechanisms Regeneration of periodontal tissue |
| title | Role of periodontal ligament fibroblasts in periodontitis: pathological mechanisms and therapeutic potential |
| title_full | Role of periodontal ligament fibroblasts in periodontitis: pathological mechanisms and therapeutic potential |
| title_fullStr | Role of periodontal ligament fibroblasts in periodontitis: pathological mechanisms and therapeutic potential |
| title_full_unstemmed | Role of periodontal ligament fibroblasts in periodontitis: pathological mechanisms and therapeutic potential |
| title_short | Role of periodontal ligament fibroblasts in periodontitis: pathological mechanisms and therapeutic potential |
| title_sort | role of periodontal ligament fibroblasts in periodontitis pathological mechanisms and therapeutic potential |
| topic | Periodontal Ligament Fibroblasts Periodontitis Pathological Mechanisms Regeneration of periodontal tissue |
| url | https://doi.org/10.1186/s12967-024-05944-8 |
| work_keys_str_mv | AT yijiehuang roleofperiodontalligamentfibroblastsinperiodontitispathologicalmechanismsandtherapeuticpotential AT yingtang roleofperiodontalligamentfibroblastsinperiodontitispathologicalmechanismsandtherapeuticpotential AT ruiqizhang roleofperiodontalligamentfibroblastsinperiodontitispathologicalmechanismsandtherapeuticpotential AT xiaowu roleofperiodontalligamentfibroblastsinperiodontitispathologicalmechanismsandtherapeuticpotential AT liyan roleofperiodontalligamentfibroblastsinperiodontitispathologicalmechanismsandtherapeuticpotential AT xilingchen roleofperiodontalligamentfibroblastsinperiodontitispathologicalmechanismsandtherapeuticpotential AT qianqiwu roleofperiodontalligamentfibroblastsinperiodontitispathologicalmechanismsandtherapeuticpotential AT yiyanchen roleofperiodontalligamentfibroblastsinperiodontitispathologicalmechanismsandtherapeuticpotential AT yingtaolv roleofperiodontalligamentfibroblastsinperiodontitispathologicalmechanismsandtherapeuticpotential AT yuansu roleofperiodontalligamentfibroblastsinperiodontitispathologicalmechanismsandtherapeuticpotential |