Advancing Therapeutic Targets in IBD: Emerging Goals and Precision Medicine Approaches
Inflammatory bowel diseases (IBD) including Crohn’s disease (CD) and ulcerative colitis (UC) are chronic, relapsing conditions characterized by dysregulated immune responses and persistent intestinal inflammation. This review aims to examine new potential therapeutic targets in IBD starting from the...
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MDPI AG
2025-01-01
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| Online Access: | https://www.mdpi.com/1424-8247/18/1/78 |
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| author | Lucia Centanni Clelia Cicerone Fabrizio Fanizzi Ferdinando D’Amico Federica Furfaro Alessandra Zilli Tommaso Lorenzo Parigi Laurent Peyrin-Biroulet Silvio Danese Mariangela Allocca |
| author_facet | Lucia Centanni Clelia Cicerone Fabrizio Fanizzi Ferdinando D’Amico Federica Furfaro Alessandra Zilli Tommaso Lorenzo Parigi Laurent Peyrin-Biroulet Silvio Danese Mariangela Allocca |
| author_sort | Lucia Centanni |
| collection | DOAJ |
| description | Inflammatory bowel diseases (IBD) including Crohn’s disease (CD) and ulcerative colitis (UC) are chronic, relapsing conditions characterized by dysregulated immune responses and persistent intestinal inflammation. This review aims to examine new potential therapeutic targets in IBD starting from the STRIDE-II statements. Key targets now include clinical remission, endoscopic remission, and biomarker normalization (such as C-reactive protein and fecal calprotectin). Moreover, histologic remission, transmural remission, and in the future molecular targets are emerging as important indicators of sustained disease control. The treatment goals for inflammatory bowel disease are varied: to relieve symptoms, prevent permanent intestinal damage, promote inflammation remission, and minimize complications. Consequently, the therapeutic targets have evolved to become broader and more ambitious. Integrating these advanced therapeutic targets has the potential to redefine IBD management by promoting deeper disease control and improved patient outcomes. Further research is essential to validate these strategies and optimize their clinical implementation. |
| format | Article |
| id | doaj-art-86382e0680fd4a76a225e06e9c9e6c6a |
| institution | Kabale University |
| issn | 1424-8247 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj-art-86382e0680fd4a76a225e06e9c9e6c6a2025-01-24T13:45:18ZengMDPI AGPharmaceuticals1424-82472025-01-011817810.3390/ph18010078Advancing Therapeutic Targets in IBD: Emerging Goals and Precision Medicine ApproachesLucia Centanni0Clelia Cicerone1Fabrizio Fanizzi2Ferdinando D’Amico3Federica Furfaro4Alessandra Zilli5Tommaso Lorenzo Parigi6Laurent Peyrin-Biroulet7Silvio Danese8Mariangela Allocca9Gastroenterology and Endoscopy, IRCCS Hospital San Raffaele, University Vita-Salute San Raffaele, 20132 Milan, ItalyGastroenterology and Endoscopy, IRCCS Hospital San Raffaele, University Vita-Salute San Raffaele, 20132 Milan, ItalyGastroenterology and Endoscopy, IRCCS Hospital San Raffaele, University Vita-Salute San Raffaele, 20132 Milan, ItalyGastroenterology and Endoscopy, IRCCS Hospital San Raffaele, University Vita-Salute San Raffaele, 20132 Milan, ItalyGastroenterology and Endoscopy, IRCCS Hospital San Raffaele, University Vita-Salute San Raffaele, 20132 Milan, ItalyGastroenterology and Endoscopy, IRCCS Hospital San Raffaele, University Vita-Salute San Raffaele, 20132 Milan, ItalyGastroenterology and Endoscopy, IRCCS Hospital San Raffaele, University Vita-Salute San Raffaele, 20132 Milan, ItalyDepartment of Gastroenterology, INFINY Institute, INSERM NGERE, CHRU de Nancy, Université de Lorraine, F-54500 Vandœuvre-lès-Nancy, FranceGastroenterology and Endoscopy, IRCCS Hospital San Raffaele, University Vita-Salute San Raffaele, 20132 Milan, ItalyGastroenterology and Endoscopy, IRCCS Hospital San Raffaele, University Vita-Salute San Raffaele, 20132 Milan, ItalyInflammatory bowel diseases (IBD) including Crohn’s disease (CD) and ulcerative colitis (UC) are chronic, relapsing conditions characterized by dysregulated immune responses and persistent intestinal inflammation. This review aims to examine new potential therapeutic targets in IBD starting from the STRIDE-II statements. Key targets now include clinical remission, endoscopic remission, and biomarker normalization (such as C-reactive protein and fecal calprotectin). Moreover, histologic remission, transmural remission, and in the future molecular targets are emerging as important indicators of sustained disease control. The treatment goals for inflammatory bowel disease are varied: to relieve symptoms, prevent permanent intestinal damage, promote inflammation remission, and minimize complications. Consequently, the therapeutic targets have evolved to become broader and more ambitious. Integrating these advanced therapeutic targets has the potential to redefine IBD management by promoting deeper disease control and improved patient outcomes. Further research is essential to validate these strategies and optimize their clinical implementation.https://www.mdpi.com/1424-8247/18/1/78new therapeutic targetsclinical remissionendoscopic remissionhistologic remissiontransmural remissiondeep remission |
| spellingShingle | Lucia Centanni Clelia Cicerone Fabrizio Fanizzi Ferdinando D’Amico Federica Furfaro Alessandra Zilli Tommaso Lorenzo Parigi Laurent Peyrin-Biroulet Silvio Danese Mariangela Allocca Advancing Therapeutic Targets in IBD: Emerging Goals and Precision Medicine Approaches Pharmaceuticals new therapeutic targets clinical remission endoscopic remission histologic remission transmural remission deep remission |
| title | Advancing Therapeutic Targets in IBD: Emerging Goals and Precision Medicine Approaches |
| title_full | Advancing Therapeutic Targets in IBD: Emerging Goals and Precision Medicine Approaches |
| title_fullStr | Advancing Therapeutic Targets in IBD: Emerging Goals and Precision Medicine Approaches |
| title_full_unstemmed | Advancing Therapeutic Targets in IBD: Emerging Goals and Precision Medicine Approaches |
| title_short | Advancing Therapeutic Targets in IBD: Emerging Goals and Precision Medicine Approaches |
| title_sort | advancing therapeutic targets in ibd emerging goals and precision medicine approaches |
| topic | new therapeutic targets clinical remission endoscopic remission histologic remission transmural remission deep remission |
| url | https://www.mdpi.com/1424-8247/18/1/78 |
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