Uncovering protein prenylation in Th1 cells: novel prenylation sites and insights into statin and farnesyltransferase inhibition

Uncovering protein prenylation in Th1 cells: novel prenylation sites and insights into statin and farnesyltransferase inhibition

Abstract Background T helper 1 (Th1) cell activation is an essential process for immune responses and is tightly regulated, including the prenylation of proteins critical for T cell function. Prenylation facilitates membrane association and protein function and, according to current consensus, is co...

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Main Authors: Jana Koch, Alessandra Ruggia, Carina Beha, Irina Wipf, Damir Zhakparov, Patrick Westermann, Svenja Schmelzer, Anja Heider, Klemens Fröhlich, Katja Baerenfaller
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Biology
Subjects:
T cells
T helper 1 cells
Immunology
Autoimmunity
Statin
Prenylation
Online Access:https://doi.org/10.1186/s12915-025-02345-1
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https://doi.org/10.1186/s12915-025-02345-1

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