Sinomenine hydrochloride improves DSS-induced colitis in mice through inhibition of the Notch signaling pathway

Sinomenine hydrochloride improves DSS-induced colitis in mice through inhibition of the Notch signaling pathway

Abstract Objective To study the therapeutic effect of sinomenine hydrochloride (SH) on dextran sodium sulfate (DSS)-induced colitis in mice as an animal model and the changes of Notch signaling pathway in colon tissue of mice after treatment. Methods Twenty-four mice were randomly divided into contr...

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Bibliographic Details
Main Authors: Linxia Xu, Wei Liu, Xixiang Huang, Tong Sun, Letian Mei, Man Liu, Zhi Ren, Meng Wang, Hailun Zheng, Qiangwu Wang, Dapeng Li, Qizhi Wang, Xiquan Ke
Format: Article
Language:English
Published: BMC 2024-12-01
Series:BMC Gastroenterology
Subjects:
Ulcerative colitis
Sinomenine hydrochloride
Notch signaling pathway
Disease activity index
Online Access:https://doi.org/10.1186/s12876-024-03546-8
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https://doi.org/10.1186/s12876-024-03546-8

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