Environmental arsenic hijacks DDX5-mediated FANCA splicing to impair R-loops resolution and drive ovarian aging

Environmental arsenic hijacks DDX5-mediated FANCA splicing to impair R-loops resolution and drive ovarian aging

Arsenic, a widespread environmental toxicant, is increasingly implicated in female reproductive dysfunction. Long-term exposure to low concentrations of arsenic leads to diminished ovarian reserve. However, the mechanisms by which arsenic exposure accelerates ovarian aging remain unclear. Here, we d...

Full description

Saved in:
Bibliographic Details
Main Authors: Tuo Zhang, Jin Niu, Lu Yang, Yuanyuan Yu, Meina He, Changfa Wu, Zengmei Cheng, Mei Pan, Zerui Hong, Jian Sun, Yuan Gao, Tengxiang Chen, Zhengrong Wang, Wei Pan
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Ovary
Arsenic
DDX5
R-loops
Genome instability
Alternative splicing
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651325009509
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

http://www.sciencedirect.com/science/article/pii/S0147651325009509

Similar Items