Gene-environment interaction in the onset of eczema in infancy: filaggrin loss-of-function mutations enhanced by neonatal cat exposure.

Gene-environment interaction in the onset of eczema in infancy: filaggrin loss-of-function mutations enhanced by neonatal cat exposure.

<h4>Background</h4>Loss-of-function variants in the gene encoding filaggrin (FLG) are major determinants of eczema. We hypothesized that weakening of the physical barrier in FLG-deficient individuals may potentiate the effect of environmental exposures. Therefore, we investigated whether...

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Main Authors: Hans Bisgaard, Angela Simpson, Colin N A Palmer, Klaus Bønnelykke, Irwin McLean, Somnath Mukhopadhyay, Christian B Pipper, Liselotte B Halkjaer, Brian Lipworth, Jenny Hankinson, Ashley Woodcock, Adnan Custovic
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-06-01
Series:PLoS Medicine
Online Access:https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.0050131&type=printable
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https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.0050131&type=printable

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