Design and bioactivity evaluation of a novel autotaxin inhibitor with anti-hepatic fibrosis effects

Abstract Autotaxin (ATX) is considered as a serum marker of hepatic fibrosis, which is positively correlated with the degree of hepatic fibrosis. However, there are no clinical studies on anti-hepatic fibrosis drugs targeting ATX. This study attempts to find novel ATX small molecule inhibitors based...

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Bibliographic Details
Main Authors: Yuzheng Liu, Dan Luo, Hongwen Leng, Chaolun Gu, Qingrong Ding, Lin Zhao, Xinxin Chao, Hanxia Wang, Yueteng He, Silu Zhu, Guanhua Ai, Weijie Peng
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-95464-2
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