Ability of soluble TREM2 and PRO-C3 as biomarkers to predict changes in MASLD activity

Ability of soluble TREM2 and PRO-C3 as biomarkers to predict changes in MASLD activity

Background & Aims: Diet and weight loss remain the primary treatment for most patients with metabolic dysfunction-associated fatty liver disease (MASLD), with one recent drug therapy approved for severe cases. However, a significant need remains for non-invasive tests (NITs) that can assist...

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Main Authors: Charlotte Wilhelmina Wernberg, Vineesh Indira Chandran, Mette Munk Lauridsen, Maria Kløjgaard Skytthe, Camilla Dalby Hansen, Johanne Kragh Hansen, Lea Ladegaard Grønkjær, Birgitte Gade Jacobsen, Tina Di Caterino, Sönke Detlefsen, Maja Thiele, Alejandro Mayorca Guiliani, Ida Falk Villesen, Diana Julie Leeming, Morten Karsdal, Jonas Heilskov Graversen, Aleksander Krag
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:JHEP Reports
Subjects:
Serial liver biopsy
Hepatic inflammation
Neoepitope biomarkers
Collagen markers
Non-alcoholic steatohepatitis
Monitoring marker
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555925001090
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