Building an international precision medicine platform trial for the acute respiratory distress syndrome (ARDS): an expert consensus project report

Building an international precision medicine platform trial for the acute respiratory distress syndrome (ARDS): an expert consensus project report

Background Almost all large-scale trials of disease-modifying therapeutic agents in critical care have failed to show benefit for patients, which may be explained in part by the clinical and biological heterogeneity inherent in virtually all critical illness syndromes. Enrichment strategies have bee...

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Main Authors: Kiran Reddy, Neil Aggarwal, Narges Alipanah-Lechner, Djillali Annane, David B Antcliffe, Daphne Babalis, J Kenneth Baillie, Abigail Beane, Lieuwe DJ Bos, Aidan Burrell, Carolyn S Calfee, Kiki Cano-Gamez, Victoria R Cornelius, Mary Cross, Emma Davenport, Lorenzo del Sorbo, Laura Esserman, Eddy Fan, Vito Fanelli, Niall D Ferguson, D Clark Files, Christoph Fisser, Shigeki Fujitani, Ewan C Goligher, Anthony C Gordon, Giacomo Grasselli, Fergus Hamilton, Rashan Haniffa, Andrea Haren, Daniel JR Harvey, Leanne M Hays, Anna Heath, Nicholas Heming, Susanne Herold, Tim Hicks, Nao Ichihara, Vinod Jaiswal, Jun Kataoka, Julian C Knight, Patrick R Lawler, Kathleen Liu, John C Marshall, David M Maslove, Michael A Matthay, Daniel F McAuley, Nuala J Meyer, Jonathan A Millar, Holger Müller-Redetzky, Alistair Nichol, John Norrie, Marlies Ostermann, Andrew Owen, Cecilia M O’Kane, Dhruv Parekh, Rachel Phillips, Duncan Richards, Bram Rochwerg, Anthony J Rostron, Hiroki Saito, Romit J Samanta, Vittorio Scaravilli, Wesley Self, Manu Shankar-Hari, A John Simpson, Pratik Sinha, Marry R Smit, Jonathan Stewart, B Taylor Thompson, István Vadász, Ed Waddingham, Steve Webb, Graham Wheeler, D Martin Witzenrath, Mark M Wurfel, Thomas R Martin
Format: Article
Language:English
Published: NIHR Journals Library 2025-07-01
Series:Efficacy and Mechanism Evaluation
Subjects:
acute respiratory distress syndrome
platform trials
precision medicine
biomarker-guided trials
intensive care
critical care
airway extubation
algorithms
biological specimen banks
biological variation
population
biomarkers
covid-19
clinical trials
phase ii as topic
cluster analysis
critical illness
cytokines
intensive care units
intubation
intratracheal
logistic models
noninvasive ventilation
outcome assessment
health care
pandemics
phenotype
pneumonia
randomized controlled trials as topic
reproducibility of results
respiration
artificial
respiratory distress syndrome
respiratory insufficiency
sepsis
simvastatin
Online Access:https://doi.org/10.3310/TTND8896
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