New models for MPNST: establishment and comprehensive characterization of two tumor cell lines

Abstract Background Malignant peripheral nerve sheath tumors (MPNSTs) are rare, invasive, and aggressive soft tissue sarcomas arising from peripheral nerves. They may occur sporadically or in association with Neurofibromatosis type 1 (NF1), in which they are the leading cause of mortality. Currently...

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Main Authors: Sara Ortega-Bertran, Edgar Creus-Bachiller, Miriam Magallón-Lorenz, Meritxell Carrió, Bernat Gel, Alberto Villanueva, Juan Carlos Lopez-Gutierrez, Anna Estival, Eduard Serra, Juana Fernández-Rodríguez, Conxi Lázaro
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Cancer Cell International
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Online Access:https://doi.org/10.1186/s12935-025-03845-4
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