Human Immune System Reconstitution in NOD/Shi-<i>Prkdc<sup>scid</sup> Il2rg<sup>em1</sup></i>/Cyagen Mice to Study HIV Infection: Challenges and Pitfalls

Human Immune System Reconstitution in NOD/Shi-<i>Prkdc<sup>scid</sup> Il2rg<sup>em1</sup></i>/Cyagen Mice to Study HIV Infection: Challenges and Pitfalls

The main challenge after engraftment of human tissues to mice is the development of graft-versus-host disease. It often occurs in an acute form, which reduces the time frame for observations. This is especially important to take into account when planning long-term studies of chronic diseases such a...

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Bibliographic Details
Main Authors: Aleksey M. Nagornykh, Marina A. Tyumentseva, Aleksandr I. Tyumentsev, Leonid A. Fedotov, Konstantin S. Karbyshev, Evgeniya A. Orlova, Liliia N. Volchkova, Lubov S. Danilova, Andrey S. Akinin, Vasiliy G. Akimkin
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Life
Subjects:
HIV
mouse model
graft-versus-host disease
peripheral blood mononuclear cells
T-helper cells
Online Access:https://www.mdpi.com/2075-1729/15/7/1129
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