Continuous collection of human mesenchymal-stromal-cell-derived extracellular vesicles from a stirred tank reactor operated under xenogeneic-free conditions for therapeutic applications

Continuous collection of human mesenchymal-stromal-cell-derived extracellular vesicles from a stirred tank reactor operated under xenogeneic-free conditions for therapeutic applications

Abstract Background Mesenchymal-stromal-cell-derived extracellular vesicles (MSC-EVs) play a key role in the paracrine effects of MSC and have demonstrated therapeutic potential in various preclinical models. However, clinical translation is hindered by manufacturing practices relying on planar cult...

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Main Authors: Cristiana Ulpiano, William Salvador, Teresa Franchi-Mendes, Min-Chang Huang, Yee-Hsien Lin, Han-Tse Lin, Carlos A. V. Rodrigues, Ana Fernandes-Platzgummer, Joaquim M. S. Cabral, Gabriel A. Monteiro, Cláudia L. da Silva
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Stem Cell Research & Therapy
Subjects:
Extracellular vesicles
Mesenchymal stromal cells
Stirred-tank reactor
Continuous collection
Scalable manufacturing
Online Access:https://doi.org/10.1186/s13287-025-04341-2
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https://doi.org/10.1186/s13287-025-04341-2

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